CAS
3374-05-8 Purity
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3374-05-8 Purity
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Homobutein
CAS
34000-39-0
Catalog Number
ACM34000390
Category
Inhibitors
Molecular Weight
286.3
Molecular Formula
C16H14O5
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Specification
Description
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation.
Synonyms
2',4,4'-TRIHYDROXY-3-METHOXY CHALCONE;3-METHOXY-2',4',4-TRIHYDROXYCHALCONE;HOMOBUTEIN;(E)-2',4,4'-trihydroxy-3-methoxychalcone;3-O-methylbutein;HOMOBUTEIN WITH HPLC;HOMOBUTEIN hplc;(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one
IUPAC Name
(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
Canonical SMILES
COC1=C(C=CC(=C1)C=CC(=O)C2=C(C=C(C=C2)O)O)O
InChI
InChI=1S/C16H14O5/c1-21-16-8-10(3-7-14(16)19)2-6-13(18)12-5-4-11(17)9-15(12)20/h2-9,17,19-20H,1H3/b6-2+
InChI Key
BWFSBUVPIAIXKJ-QHHAFSJGSA-N
Boiling Point
523.8ºC at 760 mmHg
Melting Point
207-212ºC
Flash Point
197.6ºC
Density
1.369 g/cm³
Appearance
Powder
EC Number
251-782-7
Exact Mass
286.08400
H-Bond Acceptor
5
H-Bond Donor
3
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