HMN-176

• CAS: 173529-10-7
• Catalog Number: ACM173529107
• Category: Inhibitors
• Molecular Weight: 382.43
• Molecular Formula: C20H18N2O4S
• Description: HMN-176 is an active metabolite of the synthetic antitumor compound HMN-214. HMN-176 shows potent cytotoxicity toward various human tumor cell lines, and in mitotic cells, it causes cell cycle arrest at M phase through the destruction of spindle polar bodies, followed by the induction of DNA fragmentation. However, no direct interactions of HMN-176 with tubulin are observed. Moreover, in animal models, it was observed that oral administration of the prodrug HMN-214 caused no significant nerve toxicity, a severe side effect often associated with microtubule binding agents such as Taxol and VCR.3 In Phase I clinical trials, HMN-214 has caused sensory neuropathy and ileus in some patients. However, the grade and frequency of these adverse effects were much lower than those of typical microtubule binding agents. As expected from the mechanism of action of HMN-214 (induction of G2-M arrest in dividing cells), the main adverse effect was neutropenia. (Source: CANCER RESEARCH 63, 6942Â-6947).
• Synonyms: HMN176; HMN 176; HMN-176
• IUPAC Name: (E)-4-(2-(4-methoxyphenylsulfonamido)styryl)pyridine 1-oxide
• Canonical SMILES: O=S(NC1=CC=CC=C1/C=C/C2=CC=[N+]([O-])C=C2)(C3=CC=C(OC)C=C3)=O
• InChI: InChI=1S/C20H18N2O4S/c1-26-18-8-10-19(11-9-18)27(24,25)21-20-5-3-2-4-17(20)7-6-16-12-14-22(23)15-13-16/h2-15,21H,1H3/b7-6+
• InChI Key: LBPNULPSVCDYRF-VOTSOKGWSA-N
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1), without significant effect on tubulin polymerization.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 62.81; H, 4.74; N, 7.33; O, 16.73; S, 8.38
• Exact Mass: 382.09873
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: As summarized in Table 1, HMN-176 greatly increased the duration of mitosis in both cell lines. This delay in satisfying the spindle assembly checkpoint (SAC) indicates HMN-176 negatively impacts some aspect of spindle MT assembly and/or behavior.; Reference: Mol Cancer Ther. 2009 Mar;8(3):592-601. https://pubmed.ncbi.nlm.nih.gov/19258425/
• In Vivo Activity: However, aster formation, spindle assembly, and polar body extrusion were completely inhibited in HMN-176 treated cells. Together, these data suggest HMN-176 prevents spindle assembly and meiosis in Spisula oocytes by inhibiting centrosome-dependent MT nucleation, i.e., aster formation.; Reference: Mol Cancer Ther. 2009 Mar;8(3):592-601. https://pubmed.ncbi.nlm.nih.gov/19258425/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).