Guaiacol glycidyl ether

• CAS: 2210-74-4
• Catalog Number: ACM2210744
• Category: Other Products
• Molecular Weight: 180.2g/mol
• Molecular Formula: C10H12O3
• Synonyms: GUAIACOL GLYCIDYL ETHER;[(2-methoxyphenoxy)methyl]oxirane;3-(O-METHOXYPHENOXY)-1,2-EPOXYPROPANE;O-METHOXY PHENYL CYCLOXYPROPYL ETHER;1,2-epoxy-3-(o-methoxyphenoxy)-propan;1,2-epoxy-3-(o-methoxyphenoxy)propane;3-(2-Methoxphenoxy)-1,2-epoxypropane;guajacol
• IUPAC Name: 2-[(2-methoxyphenoxy)methyl]oxirane
• Canonical SMILES: COC1=CC=CC=C1OCC2CO2
• InChI: InChI=1S/C10H12O3/c1-11-9-4-2-3-5-10(9)13-7-8-6-12-8/h2-5,8H,6-7H2,1H3
• InChI Key: RJNVSQLNEALZLC-UHFFFAOYSA-N
• Density: 1.142 g/cm³
• Appearance: White Crystalline Solid
• Complexity: 160
• Covalently-Bonded Unit Count: 1
• EC Number: 218-644-8
• Exact Mass: 180.078644g/mol
• Formal Charge: 0
• H-Bond Acceptor: 3
• H-Bond Donor: 0
• Heavy Atom Count: 13
• Monoisotopic Mass: 180.078644g/mol
• NSC Number: 133442;112256
• Rotatable Bond Count: 4
• XLogP3: 1.6

Synthetic Use

Upstream Synthesis Route 1

• 90-05-1
• 106-89-8

• 2210-74-4

Reference: [1] Organic Process Research and Development, 2012, vol. 16, # 10, p. 1660 - 1664

Upstream Synthesis Route 2

• 90-05-1
• 3132-64-7

• 2210-74-4

Reference: [1] Journal of Medicinal Chemistry, 2004, vol. 47, # 12, p. 3089 - 3104
[2] Journal of Medicinal Chemistry, 1988, vol. 31, # 2, p. 345 - 351
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 20, p. 6108 - 6115

Upstream Synthesis Route 3

• 90-05-1
• 106-89-8

• 16929-60-5
• 2210-74-4

Reference: [1] Patent: WO2008/47388, 2008, A2, . Location in patent: Page/Page column 12; 14

Downstream Synthesis Route 1

• 53673-01-1
• 2210-74-4

• 83019-70-9

Reference: [1]Large, M.S.; Smith, L.H.
[Journal of Medicinal Chemistry, 1982, vol. 25, # 11, p. 1286 - 1292]

Downstream Synthesis Route 2

• 5052-95-9
• 2210-74-4

• 77211-59-7

Reference: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 1320 - 1328

Downstream Synthesis Route 3

• 2210-74-4

• 93-14-1

Reference: [1]Journal of the Chemical Society. Chemical communications,1980,p. 1053 - 1054
[2]Journal of the American Chemical Society,1983,vol. 105,p. 586 - 593
[3]Chemical and Pharmaceutical Bulletin,2009,vol. 57,p. 1218 - 1222

* For details of the synthesis route, please refer to the original source to ensure accuracy.