Glutathione

• CAS: 70-18-8
• Catalog Number: ACM70188
• Category: Material of Cosmetics
• Molecular Weight: 307.32
• Molecular Formula: C10H17N3O6S
• Description: Antioxidant, free radical scavenging, detoxification, immunity enhancement, anti-aging, anti-cancer, anti-radiation hazards
• Synonyms: L-Glutatione
• IUPAC Name: (2S)-2-Amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
• Canonical SMILES: C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N
• InChI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
• InChI Key: RWSXRVCMGQZWBV-WDSKDSINSA-N
• Boiling Point: 754.5±60.0 °C
• Melting Point: 192-195 °C(lit.)
• Density: 1.4482 g/cm³
• Solubility: Soluble in water
• Appearance: White powder
• Application: Antioxidant, anti-aging, and whitening
• Storage: 2-8 °C
• Active Content: 95%
• Complexity: 389
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Exact Mass: 307.08380644
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 6
• Isomeric SMILES: C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N
• Monoisotopic Mass: 307.08380644
• pH: 3
• Physical State: Powder
• pKa: pK1: 2.12, pK2: 3.53, pK3: 8.66, pK4: 9.12
• Refractive Index: 1.571
• Rotatable Bond Count: 9
• Solubility In Water: Soluble
• Topological Polar Surface Area: 160 Ų

Custom Q&A

What is the molecular formula of glutathione?

The molecular formula of glutathione is C10H17N3O6S.

What is the molecular weight of glutathione?

The molecular weight of glutathione is 307.33 g/mol.

What are some synonyms for glutathione?

Some synonyms for glutathione include L-Glutathione, Glutathion, and Isethion.

What is the role of glutathione in cells?

Glutathione has many roles in cells, including conjugating to drugs to make them more soluble for excretion, serving as a cofactor for some enzymes, being involved in protein disulfide bond rearrangement, and reducing peroxides.

What is the InChIKey for glutathione?

The InChIKey for glutathione is RWSXRVCMGQZWBV-WDSKDSINSA-N.

What is the Canonical SMILES representation of glutathione?

The Canonical SMILES representation of glutathione is C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N.

What is the DrugBank ID for glutathione?

The DrugBank ID for glutathione is CHEMBL1543.

What is the FDA Global Substance Registration System (GSRS) ID for glutathione?

The FDA Global Substance Registration System (GSRS) ID for glutathione is GAN16C9B8O.

What is the KEGG ID for glutathione?

The KEGG ID for glutathione is C02471.

What is the role of glutathione as described in the description section of the reference?

Glutathione has a role as a skin lightening agent, a human metabolite, an Escherichia coli metabolite, a mouse metabolite, a geroprotector, an antioxidant, and a cofactor.

Synthetic Use

Upstream Synthesis Route 1

• 27025-41-8

• 70-18-8

Reference: [1]Journal of Biological Chemistry,1939,vol. 129,p. 393

Downstream Synthesis Route 1

• 57-48-7
• 70-18-8

• 7774-74-5
• 1003-04-9
• 872-55-9
• 109-08-0
• 620-02-0
• 5402-55-1
• 1192-62-7
• 2527-76-6
• 1072-83-9
• 28588-74-1

Reference: [1] Journal of Agricultural and Food Chemistry, 2010, vol. 58, # 5, p. 3116 - 3124

Downstream Synthesis Route 2

• 70-18-8
• 490-46-0
• 970-73-0

• 4670-05-7

Reference: [1] Journal of Agricultural and Food Chemistry, 2002, vol. 50, # 7, p. 2142 - 2148

Downstream Synthesis Route 3

• 70-18-8
• 60976-49-0

• 23094-69-1

Reference: [1] Chemical and Pharmaceutical Bulletin, 1996, vol. 44, # 1, p. 34 - 40

Downstream Synthesis Route 4

• 70-18-8

• 27025-41-8

Reference: [1]Journal of Organic Chemistry,2011,vol. 76,p. 4173 - 4177

* For details of the synthesis route, please refer to the original source to ensure accuracy.