Ganoderic Acid A

• CAS: 81907-62-2
• Catalog Number: ACM81907622
• Category: Others
• Molecular Weight: 514.65
• Molecular Formula: C30H42O7
• Description: Ganoderic acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms. For thousands of years, the fruiting bodies of Ganoderma fungi have been used in traditional medicines in East Asia. Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. There are dozens of ganoderic acids that have been isolated and characterized, of which ganoderic acid A and ganoderic acid B are the most well characterized. Some ganoderic acids have been found to possess biological activities including hepatoprotection, anti-tumor effects, and 5-alpha reductase inhibition. (Source: http://en.wikipedia.org/wiki/Ganoderic_acid).
• Synonyms: (25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oic acid
• IUPAC Name: (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid
• Canonical SMILES: C[C@H](CC(=O)C[C@@H](C)C(=O)O)[C@H]1C[C@@H]([C@@]2([C@@]1(CC(=O)C3=C2[C@H](C[C@@H]4[C@@]3(CCC(=O)C4(C)C)C)O)C)C)O
• InChI: InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1
• InChI Key: DYOKDAQBNHPJFD-JNTBEZBXSA-N
• Boiling Point: 690.1±55.0 °C
• Melting Point: 118-123 °C
• Density: 1.22 g/ml
• Solubility: Soluble in DMSO
• Appearance: Powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 69.74; H, 8.58; O, 21.68
• Exact Mass: 516.3087
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: The present data indicated that pretreatment with GAA (ganoderic acid A) notably suppressed the mRNA expression of TLR2, TLR4,; NLRP3, and caspase-1 induced by H2O2 (Figure 6(a)) in NP (nuceus pulposus) cells. Meanwhile, western blot analysis showed that; GAA could significantly inhibit the expressions of these proteins (Figure 6(b)). Thus, TLR4/NLRP3 signaling pathway activation; induced by H2O2 could be attenuated by GAA.; Reference: Bioengineered. 2022 May;13(5):11684-11693. https://pubmed.ncbi.nlm.nih.gov/35506157/
• In Vivo Activity: Compared to thinning, rupture, and basal layer congestion of gastric mucosa in the gastric and duodenal tissues of the FD (functional; dyspepsia) group, the tissues in the GAA (ganoderic acid A) and Dom (domperidone) groups revealed intact gastric structure (Figure; 2(a)). In addition, epithelial cell swelling, focal necrosis, exfoliation, and massive inflammatory cell infiltration were seen in the; duodenal tissue sections of the FD group. Upon treatment with GAA or Dom, however, these symptoms almost disappeared and only; mild hyperemia and inflammatory cell infiltration remained with intact duodenal mucosa (Figure 2(b)). Collectively, GAA could; significantly alleviate the gastric and duodenal tissue injury in FD rats.; Reference: Evid Based Complement Alternat Med. 2022 May 31;2022:2298665. https://pubmed.ncbi.nlm.nih.gov/35685728/
• pKa: 4.78±0.23
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).