FORODESINE

• CAS: 209799-67-7
• Catalog Number: ACM209799677
• Category: Inhibitors
• Molecular Weight: 266.26
• Molecular Formula: C11H14N4O4
• Description: Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels.
• Canonical SMILES: O=C1C(NC=C2[C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)=C2NC=N1
• Appearance: White to Yellow Solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Shipping: Can be shipped at room temperature, where not in use may vary.

Custom Q&A

What is the molecular formula of Forodesine?

The molecular formula of Forodesine is C11H14N4O4.

What are the synonyms of Forodesine?

The synonyms of Forodesine are Immucillin H, Fodosine, and Immucillin-H.

What is the molecular weight of Forodesine?

The molecular weight of Forodesine is 266.25 g/mol.

What is the description of Forodesine?

Forodesine is described as a highly potent, orally active, rationally designed PNP inhibitor that has shown activity in preclinical studies with malignant cells and clinical utility against T-cell acute lymphoblastic leukemia and cutaneous T-cell lymphoma.

What is the IUPAC name of Forodesine?

The IUPAC name of Forodesine is 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one.

What is the InChI of Forodesine?

The InChI of Forodesine is InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1.

What is the InChIKey of Forodesine?

The InChIKey of Forodesine is IWKXDMQDITUYRK-KUBHLMPHSA-N.

What is the canonical SMILES of Forodesine?

The canonical SMILES of Forodesine is C1=C(C2=C(N1)C(=O)NC=N2)C3C(C(C(N3)CO)O)O.

What is the CAS number of Forodesine?

The CAS number of Forodesine is 209799-67-7.

What is the NCI Thesaurus Code of Forodesine?

The NCI Thesaurus Code of Forodesine is C65755.