Fmoc-Tyr(tBu)-Thr(psiMe,Mepro)-OH

• CAS: 920519-31-9
• Catalog Number: ACM920519319-1
• Category: Amino Acids
• Molecular Weight: 600.7
• Description: This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Tyr-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction.
• Synonyms: Fmoc-Tyr(tBu)-Thr(psiMe,Mepro)-OH
• InChI: 1S/C35H40N2O7/c1-21-30(32(39)40)37(35(5,6)43-21)31(38)29(19-22-15-17-23(18-16-22)44-34(2,3)4)36-33(41)42-20-28-26-13-9-7-11-24(26)25-12-8-10-14-27(25)28/h7-18,21,28-30H,19-20H2,1-6H3,(H,36,41)(H,39,40)/t21-,29+,30+/m1/s1
• InChI Key: JYSMURJYNLWZNY-RIGQTMPJSA-N
• Application: Peptide synthesis.
• Assay: ≥97% (TLC); ≥97.0% (HPLC)
• Form: powder
• Functional Group: hydroxyl
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-8℃