Fmoc-N-Me-Ile-OH

• CAS: 138775-22-1
• Catalog Number: ACM138775221
• Category: Amino Acids
• Molecular Weight: 367.44
• Description: Building block for introduction of N-α-methyl-isoleucine amino-acid residues by Fmoc SPPS.
• Synonyms: Fmoc-N-Me-Ile-OH, N-α-Fmoc-N-α-methyl-L-isoleucine
• InChI: 1S/C22H25NO4/c1-4-14(2)20(21(24)25)23(3)22(26)27-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,4,13H2,1-3H3,(H,24,25)/t14-,20-/m0/s1
• InChI Key: IQIOLCJHRZWOLS-XOBRGWDASA-N
• Melting Point: 177-183℃
• Application: Peptide synthesis.
• Assay: ≥95.0% (acidimetric); ≥97% (TLC); ≥97.0% (HPLC)
• Form: powder
• Functional Group: Fmoc
• MDL Number: MFCD00153389
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-30℃

Synthetic Use

Upstream Synthesis Route 1

• 1220527-63-8

• 138775-22-1

Reference: [1] Amino Acids, 2010, vol. 38, # 1, p. 133 - 143

Upstream Synthesis Route 2

• 1208119-61-2
• 28920-43-6

• 138775-22-1

Reference: [1] Journal of Organic Chemistry, 2010, vol. 75, # 5, p. 1386 - 1392

Upstream Synthesis Route 3

• 4125-98-8
• 82911-69-1

• 138775-22-1

Reference: [1] Tetrahedron, 1999, vol. 55, # 2, p. 413 - 422
[2] Tetrahedron, 2003, vol. 59, # 28, p. 5241 - 5249

Upstream Synthesis Route 4

• 852852-81-4
• 186581-53-3
• 28920-43-6

• 138775-22-1

Reference: [1]Angewandte Chemie,1995,vol. 107,p. 2313 - 2317

Downstream Synthesis Route 1

• 71989-23-6
• 71989-35-0
• 75-36-5
• 138775-22-1

• 817204-15-2

Reference: [1]Journal of Organic Chemistry,2007,vol. 72,p. 3723 - 3728

Downstream Synthesis Route 2

• 138775-22-1

• 220663-31-0

Reference: [1]Organic and Biomolecular Chemistry,2007,vol. 5,p. 1416 - 1426

* For details of the synthesis route, please refer to the original source to ensure accuracy.