Specification
Description
A novel derivative for the introduction of trimethyl-lysine during Fmoc SPPS. Ref contains methods and protocols for the synthesis of arrays of histone-related peptides containing methylated arginine and lysine-residues.
Synonyms
Fmoc-Lys(Me₃Cl)-OH, N-α-Fmoc-N-ε-trimethyl-N-L-lysine · chloride
InChI
1S/C24H30N2O4.ClH/c1-26(2,3)15-9-8-14-22(23(27)28)25-24(29)30-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21;/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H-,25,27,28,29);1H/t22-;/m0./s1
InChI Key
XUJRNPVABVHOAJ-FTBISJDPSA-N
Application
Peptide synthesis.
Assay
≥95% (TLC)
≥95.0% (HPLC)
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Type
Unusual Amino Acids, Methylated Amino Acids