Fmoc-Lys(biotin)-OH

• CAS: 146987-10-2
• Catalog Number: ACM146987102
• Category: Amino Acids
• Molecular Weight: 594.72
• Molecular Formula: C31H38N4O6S
• Description: A modified lysine derivative for the preparation of biotin-labeled peptides by Fmoc SPPS.
• Synonyms: Fmoc-Lys(biotin)-OH, N-α-Fmoc-N-ε-biotinyl-L-lysine
• Canonical SMILES: C1C2C(C(S1)CCCCC(=O)NCCCCC(C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)NC(=O)N2
• InChI: 1S/C31H38N4O6S/c36-27(15-6-5-14-26-28-25(18-42-26)33-30(39)35-28)32-16-8-7-13-24(29(37)38)34-31(40)41-17-23-21-11-3-1-9-19(21)20-10-2-4-12-22(20)23/h1-4,9-12,23-26,28H,5-8,13-18H2,(H,32,36)(H,34,40)(H,37,38)(H2,33,35,39)/t24-,25-,26-,28-/m0/s1
• InChI Key: OFIBQNGDYNGUEZ-OBXRUURASA-N
• Boiling Point: 936.2±65.0 ℃at 760 mmHg
• Melting Point: 183 ℃
• Flash Point: 520.0±34.3 ℃
• Density: 1.3±0.1 g/cm³
• Application: Peptide synthesis.
• Assay: ≥85.0% (HPLC); ≥95% (TLC)
• Exact Mass: 594.251221
• Form: powder
• Functional Group: biotin
• LogP: 3.2
• MDL Number: MFCD00270741
• PSA: 171.16
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Refractive Index: 1.594
• Storage Temperature: 2-30℃
• Type: Unlabeled Standard Amino Acids, Lysine (Lys)
• Vapor Pressure: 0.0±0.3 mmHg at 25℃
• WGK Germany: 3

Synthetic Use

Upstream Synthesis Route 1

• 105047-45-8
• 35013-72-0

• 146987-10-2

Reference: [1] Chemical Communications, 2006, # 7, p. 717 - 719
[2] Chemical Communications, 2017, vol. 53, # 36, p. 5020 - 5023
[3] Chemistry - A European Journal, 2017, vol. 23, # 45, p. 10906 - 10914

Upstream Synthesis Route 2

• 105047-45-8
• 58-85-5

• 146987-10-2

Reference: [1] Journal of Chemical Research, 2010, # 6, p. 348 - 350

Downstream Synthesis Route 1

• 146987-10-2

• 576-19-2

Reference: [1] Chemical Communications, 2017, vol. 53, # 36, p. 5020 - 5023
[2] Chemistry - A European Journal, 2017, vol. 23, # 45, p. 10906 - 10914

* For details of the synthesis route, please refer to the original source to ensure accuracy.