Fmoc-Leu-OH

• CAS: 35661-60-0
• Catalog Number: ACM35661600-1
• Category: Amino Acids
• Molecular Weight: 353.41
• Molecular Formula: C21H23NO4
• Description: High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Standard building block for introduction of leucine amino-acid residues by Fmoc SPPS.
• Synonyms: Fmoc-Leu-OH, N-α-Fmoc-L-leucine
• InChI: 1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)
• InChI Key: CBPJQFCAFFNICX-UHFFFAOYSA-N
• Melting Point: 145-153℃
• Application: Peptide synthesis.
• Assay: ≥98% (TLC); ≥98.0% (acidimetric); ≥99.0% (HPLC)
• Form: powder
• Functional Group: Fmoc
• MDL Number: MFCD00037133
• Quality Level: 400
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-30℃
• Type: Unlabeled Standard Amino Acids, Leucine (Leu)

Synthetic Use

Upstream Synthesis Route 1

• 61-90-5

• 35661-60-0

Reference: [1] Tetrahedron Letters, 2017, vol. 58, # 16, p. 1600 - 1603

Downstream Synthesis Route 1

• 35661-60-0

• 687-51-4

Reference: [1] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 2841 - 2849

Downstream Synthesis Route 2

• 35661-60-0
• 71989-23-6

• 36077-41-5

Reference: [1] Marine Drugs, 2013, vol. 11, # 12, p. 4834 - 4857

* For details of the synthesis route, please refer to the original source to ensure accuracy.