Structure

Fmoc-Hyp(tBu)-OH

CAS
122996-47-8
Catalog Number
ACM122996478
Category
Amino Acids
Molecular Weight
409.47
Molecular Formula
C24H27NO5

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Specification

Description
Standard building block for introduction of hydroxyproline amino-acid residues by Fmoc SPPS.
Synonyms
Fmoc-Hyp(tBu)-OH, N-α-Fmoc-O-t.-butyl-L-trans-4-hydroxyproline, Fmoc-(2S,4R)-(-)-4-t-butoxypyrrolidine-2-carboxylic acid
InChI
1S/C24H27NO5/c1-24(2,3)30-15-12-21(22(26)27)25(13-15)23(28)29-14-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,15,20-21H,12-14H2,1-3H3,(H,26,27)/t15-,21+/m1/s1
InChI Key
WPBXBYOKQUEIDW-VFNWGFHPSA-N
Melting Point
63℃
Application
Peptide synthesis.
Assay
≥95.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)
Form
powder
Functional Group
hydroxyl
MDL Number
MFCD00151930
Quality Level
200
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Storage Temperature
15-25℃
Type
Unusual Amino Acids, Analogs of Proline

Downstream Synthesis Route 1

  • 771-61-9
  • 122996-47-8
  • 147836-80-4

Reference: [1]Current Patent Assignee: DIEVINI HOPP BIOTECH HOLDING GMBH & CO. KG - WO2017/89607, 2017, A1
Location in patent: Paragraph 00131
[2]Franzyk, Henrik; Meldal, Morten; Paulsen, Hans; Bock, Klaus
[Journal of the Chemical Society. Perkin transactions I, 1995, # 22, p. 2883 - 2898]

* For details of the synthesis route, please refer to the original source to ensure accuracy.

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