Fmoc-Hyp-OH

• CAS: 88050-17-3
• Catalog Number: ACM88050173
• Category: Amino Acids
• Molecular Weight: 353.37
• Description: Building block for introduction of hydroxyproline amino-acid residues by Fmoc SPPS.
• Synonyms: Fmoc-Hyp-OH, N-α-Fmoc-L-trans-4-hydroxyproline
• InChI: 1S/C20H19NO5/c22-12-9-18(19(23)24)21(10-12)20(25)26-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,12,17-18,22H,9-11H2,(H,23,24)/t12-,18+/m1/s1
• InChI Key: GOUUPUICWUFXPM-XIKOKIGWSA-N
• Melting Point: 189℃
• Application: Peptide synthesis.
• Assay: ≥95.0% (acidimetric); ≥98% (TLC); ≥98.0% (HPLC)
• Form: powder
• Functional Group: hydroxyl
• MDL Number: MFCD00151929
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-30℃

Synthetic Use

Upstream Synthesis Route 1

• 28920-43-6
• 51-35-4

• 88050-17-3

Reference: [1] Tetrahedron Letters, 1994, vol. 35, # 51, p. 9509 - 9512
[2] Angewandte Chemie - International Edition, 2009, vol. 48, # 10, p. 1784 - 1787
[3] Patent: US9518048, 2016, B2, . Location in patent: Page/Page column 24

Upstream Synthesis Route 2

• 51-35-4

• 88050-17-3

Reference: [1] Patent: US6316626, 2001, B1,

Downstream Synthesis Route 1

• 67-56-1
• 88050-17-3

• 122350-59-8

Reference: [1] Journal of Fluorine Chemistry, 1997, vol. 82, # 2, p. 125 - 130

Downstream Synthesis Route 2

• 88050-17-3

• 898529-45-8

Reference: [1]Tetrahedron Letters,2006,vol. 47,p. 4069 - 4073
[2]Journal of Medicinal Chemistry,2007,vol. 50,p. 2089 - 2099

* For details of the synthesis route, please refer to the original source to ensure accuracy.