Fmoc-D-His(Clt)-OH

CAS

1272755-56-2

Catalog Number

ACM1272755562

Category

Amino Acids

Molecular Weight

654.15

Molecular Formula

C40H32ClN3O4

MSDS COA Spec Sheet

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Specification

Description

Building block for introduction of D-histidine by Fmoc SPPS. The Clt group is more stable to acid than Trt and its use avoids the formation of partially protected histidine peptides during the preparation of protected fragments.

Synonyms

Fmoc-D-His(Clt)-OH, N-α-Fmoc-N-im-2-chlorotrityl-D-histidine

IUPAC Name

(2R)-3-[1-[(2-chlorophenyl)-diphenylmethyl]imidazol-4-yl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid

Canonical SMILES

C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=C(N=C4)CC(C(=O)O)NC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57

InChI

1S/C40H32ClN3O4/c41-36-22-12-11-21-35(36)40(27-13-3-1-4-14-27,28-15-5-2-6-16-28)44-24-29(42-26-44)23-37(38(45)46)43-39(47)48-25-34-32-19-9-7-17-30(32)31-18-8-10-20-33(31)34/h1-22,24,26,34,37H,23,25H2,(H,43,47)(H,45,46)/t37-/m1/s1

InChI Key

SYGADBVEKBWUKO-DIPNUNPCSA-N

Application

Peptide synthesis.

Form

powder

Functional Group

Fmoc

Quality Level

200

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis