Specification
Description
Fmoc-D-Glu-ODmab is a glycine-extended peptide that is used as a resin-bound peptide for solid-phase peptide synthesis. The D-glutamic acid residue has a higher chemical stability compared to L-glutamic acid, which makes it a suitable component for peptide synthesis. The Fmoc group serves as a protecting group for the amino group, which is removed during the peptide elongation process. The ODmab group serves as a C-terminal protecting group that can be removed using mild acidic conditions.
Synonyms
Fmoc-D-Glu-ODmab, N-α-Fmoc-D-glutamic acid α-4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-amino} benzyl ester
IUPAC Name
(4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[[4-[[1-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-3-methylbutylidene]amino]phenyl]methoxy]-5-oxopentanoic acid
Canonical SMILES
CC(C)CC(=NC1=CC=C(C=C1)COC(=O)C(CCC(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C5=C(CC(CC5=O)(C)C)O
InChI
1S/C40H44N2O8/c1-24(2)19-33(37-34(43)20-40(3,4)21-35(37)44)41-26-15-13-25(14-16-26)22-49-38(47)32(17-18-36(45)46)42-39(48)50-23-31-29-11-7-5-9-27(29)28-10-6-8-12-30(28)31/h5-16,24,31-32,43H,17-23H2,1-4H3,(H,42,48)(H,45,46)/t32-/m1/s1
InChI Key
YJZSSXBJRHSYIF-JGCGQSQUSA-N
Application
Peptide synthesis.
Assay
≥95.0% (HPLC)
≥97% (TLC)
Functional Group
carboxylic acid
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Storage Temperature
15-25℃