Fmoc-2-cyano-L-phenylalanine

• CAS: 401933-16-2
• Catalog Number: ACM401933162
• Category: Amino Acids
• Molecular Weight: 412.4
• Molecular Formula: C25H20N2O4
• Description: Fmoc-2-cyano-L-phenylalanine (Fmoc-Cy-OR) is a protected derivative of L-phenylalanine, which is widely used in the field of peptide synthesis. Fmoc-Cy-OR is a relatively new amino acid (AA) that has been introduced in the field of solid-phase peptide synthesis (SPPS). Fmoc stands for the 9-fluorenylmethyloxycarbonyl, which is a protecting group used to protect the α-amino group of the AA during SPPS. This protects the AA from reaction with other reagents when amino acids are coupled in peptide synthesis reactions.
• Synonyms: Fmoc-D-2-cyanophenylalanine, 2-Cyano-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine, (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-cyanophenyl)propanoic acid, Fmoc-2-cyano-L-phenylalanine, Fmoc-L-2-Cyanophenylalanine, Fmoc-Phe(2-CN)-OH
• IUPAC Name: (2S)-3-(2-cyanophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
• Canonical SMILES: C1=CC=C(C(=C1)CC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C#N
• InChI: 1S/C25H20N2O4/c26-14-17-8-2-1-7-16(17)13-23(24(28)29)27-25(30)31-15-22-20-11-5-3-9-18(20)19-10-4-6-12-21(19)22/h1-12,22-23H,13,15H2,(H,27,30)(H,28,29)/t23-/m0/s1
• InChI Key: ACFGBBASKOIPEW-QHCPKHFHSA-N
• Boiling Point: 666.0±55.0 ℃at 760 mmHg
• Flash Point: 356.6±31.5 ℃
• Density: 1.4±0.1 g/cm³
• Application: Fmoc-Cy-OR is widely used in the field of peptide synthesis, specifically in the construction of peptidomimetics due to its structural similarities to various natural peptides.
• Exact Mass: 412.142303
• Functional Group: Fmoc
• LogP: 4.84
• MDL Number: MFCD01863771
• PSA: 99.42
• Refractive Index: 1.672
• Storage Temperature: 4 ℃
• Type: Unusual Amino Acids, Analogs of Phenylalanine and Tyrosine
• Vapor Pressure: 0.0±2.1 mmHg at 25℃