Structure

Fmoc-Asp(OtBu)-OH

CAS
71989-14-5
Catalog Number
ACM71989145-1
Category
Amino Acids
Molecular Weight
411.45
Molecular Formula
C23H25NO6

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Specification

Description
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.
Standard building block for introduction of aspartic acid amino-acid residues by Fmoc SPPS.
Synonyms
Fmoc-Asp(OtBu)-OH, N-α-Fmoc-L-aspartic acid β-t.-butyl ester
InChI
1S/C23H25NO6/c1-23(2,3)30-20(25)12-19(21(26)27)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,26,27)/p-1/t19-/m0/s1
InChI Key
FODJWPHPWBKDON-IBGZPJMESA-M
Melting Point
143-150℃
Application
Peptide synthesis.
Assay
≥98% (TLC)
≥98.0% (acidimetric)
≥99.0% (HPLC)
Form
powder
Functional Group
carboxylic acid
MDL Number
MFCD00037131
Quality Level
400
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Storage Temperature
2-30℃
Type
Unlabeled Standard Amino Acids, Aspartic Acid (Asp)

Upstream Synthesis Route 1

  • 144120-52-5
  • 71989-14-5

Reference: [1] Synlett, 2014, vol. 25, # 16, p. 2319 - 2322

Upstream Synthesis Route 2

  • 82911-69-1
  • 3057-74-7
  • 71989-14-5

Reference: [1] Synthetic Communications, 2009, vol. 39, # 11, p. 2022 - 2031
[2] Chemical and Pharmaceutical Bulletin, 1996, vol. 44, # 11, p. 2189 - 2191

Downstream Synthesis Route 1

  • 71989-14-5
  • 136083-57-3

Reference: [1] Chemistry - A European Journal, 2015, vol. 21, # 31, p. 11014 - 11016
[2] Journal of Peptide Science, 2010, vol. 16, # 3, p. 159 - 164
[3] Organic Letters, 2012, vol. 14, # 24, p. 6346 - 6349

Downstream Synthesis Route 2

  • 20866-48-2
  • 35661-40-6
  • 71989-14-5
  • 125238-99-5
  • 110116-75-1

Reference: [1]Journal of Medicinal Chemistry,1987,vol. 30,p. 2094 - 2099

* For details of the synthesis route, please refer to the original source to ensure accuracy.

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