Eleclazine HCl

• CAS: 1448754-43-5
• Catalog Number: ACM1448754435
• Category: Inhibitors
• Molecular Weight: 451.83
• Molecular Formula: C21H17ClF3N3O3
• Description: Eleclazine HCl is a novel late Na+ current inhibitor.
• Synonyms: Eleclazine Hydrochloride; Eleclazine HCl; GS-6615; GS 6615; GS6615
• IUPAC Name: 4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one hydrochloride
• Canonical SMILES: O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13.[H]Cl
• InChI: InChI=1S/C21H16F3N3O3.ClH/c22-21(23,24)30-16-5-2-14(3-6-16)15-4-7-18-17(12-15)20(28)27(10-11-29-18)13-19-25-8-1-9-26-19;/h1-9,12H,10-11,13H2;1H
• InChI Key: ZRYHNOXHGYUHFF-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >3 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 1443211-72-0 (free base); 1448754-43-5 (HCl)
• Biological Target: Eleclazine hydrochloride is a novel late Na+ current inhibitor with IC50 value of 0.7 uM.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 55.82; H, 3.79; Cl, 7.85; F, 12.61; N, 9.30; O, 10.62
• Exact Mass: 451.0911
• HS Tariff Code: 2934.99.03.00
• In Vitro Activity: TBD
• In Vivo Activity: Eleclazine (10 μM) inhibited INa in atrial and ventricular myocytes in a use-dependent manner consistent with preferential activated state block. Eleclazine produced voltage-dependent instantaneous inhibition in atrial and ventricular myocytes; it caused a negative shift in voltage of half-maximal inactivation and slowed the recovery of INa from inactivation in both cell types.; Reference: Heart Rhythm O2. 2020 Aug;1(3):206-214. https://pubmed.ncbi.nlm.nih.gov/32864638/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).