Ebselen

• CAS: 60940-34-3
• Catalog Number: ACM60940343
• Category: Inhibitors
• Molecular Weight: 274.18
• Molecular Formula: C₁₃H₉NOSe
• Description: Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM).Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity.
• Synonyms: 2-phenyl-2-benzisoselenazol-3(2h)-one;PZ51;2-phenyl-benzo[d]isoselenazol-3-one;2-PHENYL-1,2-BENZISOSELENAZOL-3(2H)-ONE;EBSELEN;EBSELEN (PZ51, 2-PHENYL-1,2-BENZISOSELEN AZOL-3(2H)-ONE);EBSELEN 99%;2-phenyl-1,2-benzisoselenazol-
• IUPAC Name: 2-phenyl-1,2-benzoselenazol-3-one
• Canonical SMILES: C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
• InChI Key: DYEFUKCXAQOFHX-UHFFFAOYSA-N
• Boiling Point: 402.8ºC at 760 mmHg
• Melting Point: 178-181°C
• Flash Point: 197.4ºC
• Appearance: light yellow solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• EC Number: 612-054-8
• Exact Mass: 274.98500
• Hazard Statements: T,N,Xi
• Safety Description: 20/21-28-45-60-61-28A-36/37-26
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Stability: Stable at room temperature in closed containers under normal storage and handling conditions.
• Supplemental Hazard Statements: H301-H331-H373-H410-H400
• Symbol: GHS06,GHS08,GHS09
• WGK Germany: 3

Custom Q&A

What is the molecular formula of Ebselen?

The molecular formula of Ebselen is C13H9NOSe.

What are the synonyms of Ebselen?

The synonyms of Ebselen are 2-Phenyl-1,2-benzisoselenazol-3(2H)-one, 2-phenylbenzo[d][1,2]selenazol-3(2H)-one, and Ebselenum.

What is the molecular weight of Ebselen?

The molecular weight of Ebselen is 274.19 g/mol.

When was Ebselen created?

Ebselen was created on March 25, 2005.

What is the role of Ebselen?

Ebselen has multiple roles, including being a neuroprotective agent, an apoptosis inducer, an anti-inflammatory drug, an antioxidant, a hepatoprotective agent, a genotoxin, a radical scavenger, and an enzyme mimic.

What is Ebselen investigated for in terms of medical treatment?

Ebselen has been investigated for the treatment of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus.

What are the properties and activities of Ebselen?

Ebselen has anti-inflammatory, anti-oxidant, and cytoprotective activities. It acts as a glutathione peroxidase mimetic, inhibits the activity of enzymes such as nitric oxide synthase, 5-lipoxygenase, cyclooxygenase, and protein kinase C. It also neutralizes free radicals and may have neuroprotective effects.

What is the IUPAC name of Ebselen?

The IUPAC name of Ebselen is 2-phenyl-1,2-benzoselenazol-3-one.

What is the InChI of Ebselen?

The InChI of Ebselen is InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H.

What is the CAS number of Ebselen?

The CAS number of Ebselen is 60940-34-3.