Dup-721

• CAS: 104421-21-8
• Catalog Number: ACM104421218
• Category: Others
• Molecular Weight: 276.29
• Molecular Formula: C14H16N2O4
• Description: Dup-721 is a new antimicrobial agent belonging to the oxazolidinone series, a new class of synthetic antibacterial agents.
• Synonyms: Dup-721; Dup721; Dup 721
• IUPAC Name: (S)-N-((3-(4-acetylphenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
• Canonical SMILES: CC(C1=CC=C(N2C[C@H](CNC(C)=O)OC2=O)C=C1)=O
• InChI: InChI=1S/C14H16N2O4/c1-9(17)11-3-5-12(6-4-11)16-8-13(20-14(16)19)7-15-10(2)18/h3-6,13H,7-8H2,1-2H3,(H,15,18)/t13-/m0/s1
• InChI Key: POXUJOYUVLWPQN-ZDUSSCGKSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis.
• Drug Formulation: To be determined
• Elemental Analysis: C, 60.86; H, 5.84; N, 10.14; O, 23.16
• Exact Mass: 276.111
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: At concentrations ranging from 1.5 to 4 micrograms/ml, DuP-721 inhibited equally the strains of Mycobacterium tuberculosis susceptible and resistant to conventional antituberculosis drugs. DuP-721 inhibited M. gordonae and M. fortuitum at 3.9 micrograms/ml, M. kansasii at 1.95, and M. scrofulaceum at 15.6 micrograms/ml. It was not active against M. avium and M. intracellulare at concentrations of 250 micrograms/ml. The inhibition of the metabolism of M. tuberculosis as indicated by the liquid scintillation radiometric method was 56% at fourfold the minimum inhibitory concentration (MIC) of DuP-721 that compared well to that of the fourfold MIC concentrations of rifampicin and isoniazid. The in vitro activity of DuP-721 was not affected by reducing the pH from 6.8 to 5.5.; Reference: Diagn Microbiol Infect Dis. Nov-Dec 1991;14(6):465-71. https://pubmed.ncbi.nlm.nih.gov/1802533/
• In Vivo Activity: In mice infected with M. tuberculosis, the 50% effective dose (ED50) for DuP-721 was 13.2 mg/kg when administered daily beginning 4 hr postinfection for 17 days. The ED50 was 71.8 mg/kg when DuP-721 was administered only on days 11 and 12 postinfection. A 100% survival rate was obtained at 50 and 160 mg/kg when DuP-721 was administered daily for 17 days, and only on days 11 and 12 after the infection, respectively. The increase in the survival time by DuP-721 at 100 mg/kg (eightfold the ED50 dose) when administered daily for 17 days beginning 4 hr after infection was inferior to that by eightfold the ED50 dose of rifampicin and isoniazid administered on days 11 and 12 postinfection. These results indicate that DuP-721 is protective against M. tuberculosis infection in mice.; Reference: Diagn Microbiol Infect Dis. Nov-Dec 1991;14(6):465-71. https://pubmed.ncbi.nlm.nih.gov/1802533/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).