DUN61488

• CAS: 1807861-48-8
• Catalog Number: ACM1807861488
• Category: Others
• Molecular Weight: 440.47
• Molecular Formula: C24H23F3N4O
• Description: DUN61488, also known as 2,4,6,7,8,9-Hexahydro-7-(phenylmethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one is a chemical reagent for research use.
• Synonyms: DUN61488; DUN-61488; DUN 61488
• IUPAC Name: 2,4,6,7,8,9-Hexahydro-7-(phenylmethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
• Canonical SMILES: O=C1N(CC2=CC=C(C(F)(F)F)C=C2)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4
• InChI: InChI=1S/C24H23F3N4O/c25-24(26,27)19-8-6-18(7-9-19)15-31-22(32)20-16-29(14-17-4-2-1-3-5-17)12-10-21(20)30-13-11-28-23(30)31/h1-9H,10-16H2
• InChI Key: DFULPGUTXZTYKA-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: ONC212, a fluorinated-ONC201 analogue, is a promising anti-cancer agent and also a selective agonist of GPR132.
• Drug Formulation: To be determined
• Elemental Analysis: C, 65.44; H, 5.26; F, 12.94; N, 12.72; O, 3.63
• Exact Mass: 440.1824
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: ONC-212 induced a significant (P < .05) accumulation of cells from both the OSU-CLL and OSU-CLL-TP53ko lines in G0/G1, with a concomitant decrease in the proportion of cells in G2/M at each of the three time points (P < .05; Figure 2A). In the TP53ko cells, a significant (P < .05) increase in the proportion of cells in S phase was also observed with ONC-212 treatment at each time point.; Reference: EJHaem. 2021 Jan 14;2(1):81-93. https://pubmed.ncbi.nlm.nih.gov/35846080/
• In Vivo Activity: Immunohistochemical analyses of Ki67 and caspase-3 demonstrated that ONC212 reduced tumor-cell proliferation and induced apoptosis in UACC-903 and MALME xenografts to a greater extent than ONC201 (Fig. 7d, Fig. S4c).; Reference: Cell Cycle. 2017 Oct 2;16(19):1790-1799. https://pubmed.ncbi.nlm.nih.gov/28489985/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).