Dictamine

• CAS: 484-29-7
• Catalog Number: ACM484297-1
• Category: Inhibitors
• Molecular Weight: 199.21
• Molecular Formula: C12H9NO2
• Description: Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.IC50 value:Target:Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml . Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis .
• Synonyms: 4-Methoxyfuro[2,3-b]quinoline
• IUPAC Name: 4-Methoxyfuro[2,3-b]quinoline
• Canonical SMILES: COC1=C2C=COC2=NC3=CC=CC=C31
• InChI: InChI=1S/C12H9NO2/c1-14-11-8-4-2-3-5-10(8)13-12-9(11)6-7-15-12/h2-7H,1H3
• InChI Key: WIONIXOBNMDJFJ-UHFFFAOYSA-N
• Boiling Point: 337 °C
• Melting Point: 133 °C
• Density: 1.19 g/ml
• Appearance: Powder
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• pKa: 7.24±0.40
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: Plantsother families

Synthetic Use

Upstream Synthesis Route 1

• 186581-53-3
• 530-52-9

• 484-74-2
• 484-29-7

Reference: [1]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1953,vol. 73,p. 63
Chem.Abstr.,1953,p. 10544

Upstream Synthesis Route 2

• 111163-82-7

• 484-29-7

Reference: [1]Journal of the Chemical Society,1957,p. 2177,2182

Upstream Synthesis Route 3

• 63536-51-6

• 484-29-7

Reference: [1]Bulletin of the Chemical Society of Japan,1957,vol. 30,p. 708,710
[2]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1987,vol. 26,p. 910 - 913
[3]Journal of the Chemical Society,1957,p. 2177,2182