Dichlorphenamide

• CAS: 120-97-8
• Catalog Number: ACM120978
• Category: Main Products
• Molecular Weight: 305.16
• Molecular Formula: C₆H₆Cl₂N₂O₄S₂
• Synonyms: 4,5-dichlorobenzene-1,3-disulfonamide; Diclofenamide
• IUPAC Name: 4,5-dichlorobenzene-1,3-disulfonamide
• Canonical SMILES: C1=C(C=C(C(=C1S(=O)(=O)N)Cl)Cl)S(=O)(=O)N
• InChI Key: GJQPMPFPNINLKP-UHFFFAOYSA-N
• Boiling Point: 590.5ºC at 760 mmHg
• Melting Point: 239-241ºC
• Flash Point: 310.9ºC
• Density: 1.782 g/cm³
• Appearance: white or nearly white crystalline powder
• EC Number: 204-440-6
• Exact Mass: 303.91500
• Hazard Statements: Xn: Harmful
• Safety Description: 36

Case Study

Controlled Trials of Dichlorophenamide for Periodic Paralysis

Sansone V A, et al. Neurology, 2016, 86(15), 1408-1416.

Two multicenter randomized, double-blind, placebo-controlled trial were conducted to determine the short-term and long-term effects of dichlorophenamide (DCP) on the frequency of episodes and quality of life in hyperkalemic (HYP) and hypokalemic (HOP) periodic paralysis.
Experimental methods and results
· In two multicenter randomized, double-blind, placebo-controlled trials lasting 9 weeks, the effectiveness of dichlorophenamide (DCP) in the treatment of periodic paralysis was evaluated. The main outcome variable measured was the mean number of attacks per week during the last 8 weeks of the double-blind phase. 44 HOP and 21 HYP participants were enrolled in the study.
· The results showed that the median attack rate was significantly lower in HOP participants on DCP compared to those on placebo (0.3 vs 2.4, p = 0.02). The Physical Component Summary score of the Short Form-36 also improved significantly in HOP participants receiving DCP. In HYP participants, the median attack rate was lower on DCP compared to placebo (0.9 vs 4.8), although the difference was not statistically significant.
· In both trials, there were no notable impacts of DCP on muscle strength or muscle mass. The most common adverse events reported were paresthesia and confusion, with higher incidence rates in the DCP group compared to the placebo group.

Niclosamide and Dichlorophenamide as Corrosion Inhibitors for Carbon Steel in Hydrochloric Acid Solution

Fouda A S, et al. SN Applied Sciences, 2021, 3, 1-20.

This work investigated the effects of amide compounds (niclosamide and dichlorophenamide) as corrosion inhibitors on carbon steel in 1.0 M hydrochloric acid solution and verified the corrosion protection process of carbon steel by amide compounds. mong them, the highest inhibition efficiency of niclosamide and dichlorophenamide was 99% and 98.8%, respectively.
Corrosion inhibition mechanism
· The corrosion inhibition mechanism involves the physical or chemical adsorption of investigated compounds on the metal surface, replacing water molecules and forming a protective barrier film. Physical adsorption involves electrostatic interactions between the metal surface charges and inhibitor molecules, while chemical adsorption involves electron pairs on heteroatoms, π-electrons of multiple bonds, and phenyl groups bonding with iron. The values of ΔGads suggest a combination of physical and chemical adsorption.
· In acidic solutions, Cl- ions may initially adsorb on the positively charged steel surface, followed by the adsorption of protonated inhibitor molecules through electrostatic attraction and donation of electrons to iron atoms. The efficiency of inhibition is higher in Niclosamide (comp. 1) compared to Dichlorphenamide (comp.2) due to its larger molecular size and containing two benzene rings, providing more coverage over the steel surface.

Custom Q&A

What is the molecular formula of dichlorphenamide?

The molecular formula of dichlorphenamide is C6H6Cl2N2O4S2.

What is the molecular weight of dichlorphenamide?

The molecular weight of dichlorphenamide is 305.2 g/mol.

What is the chemical structure of dichlorphenamide?

The chemical structure of dichlorphenamide is a benzene ring with two chlorine atoms and two sulfonamide groups attached.

What is the IUPAC name of dichlorphenamide?

The IUPAC name of dichlorphenamide is 4,5-dichlorobenzene-1,3-disulfonamide.

What is the mechanism of action of dichlorphenamide?

The mechanism of action of dichlorphenamide is as a carbonic anhydrase inhibitor.

What is the CAS number of dichlorphenamide?

The CAS number of dichlorphenamide is 120-97-8.

What is the EC number of dichlorphenamide?

The EC number of dichlorphenamide is 204-440-6.

What is the UNII of dichlorphenamide?

The UNII of dichlorphenamide is VVJ6673MHY.

What is the InChIKey of dichlorphenamide?

The InChIKey of dichlorphenamide is GJQPMPFPNINLKP-UHFFFAOYSA-N.

What is the ChEMBL ID of dichlorphenamide?

The ChEMBL ID of dichlorphenamide is CHEMBL17.

Synthetic Use

Upstream Synthesis Route 1

• 70269-54-4

• 120-97-8

Reference: [1]Patent: US2835702,1956,