Dexmedetomidine hydrochloride

• CAS: 145108-58-3
• Catalog Number: ACM145108583-1
• Category: Active Pharmaceutical Ingredient (API)
• Molecular Weight: 236.74
• Molecular Formula: C13H17ClN2
• Synonyms: (+)-Medetomidine Hydrochloride; (S)-4-(α,2,3-Trimethybenzyl)-1H-imidazole Hydrochloride; (S)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Hydrochloride
• Melting Point: 156-160°C
• Physical State: Solid
• Standard: CP & EP

Synthetic Use

Downstream Synthesis Route 1

• 302-79-4
• 123-30-8

• 65646-68-6

Reference: [1] Synthetic Communications, 1998, vol. 28, # 16, p. 2945 - 2958
[2] Chemical and Pharmaceutical Bulletin, 2004, vol. 52, # 5, p. 501 - 506
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4378 - 4387

Downstream Synthesis Route 2

• 302-79-4

• 65646-68-6

Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 3, p. 836 - 840
[2] Chemical and Pharmaceutical Bulletin, 2004, vol. 52, # 5, p. 501 - 506
[3] Journal of Pharmaceutical Sciences, 1984, vol. 73, # 6, p. 745 - 751

Downstream Synthesis Route 3

• 186581-53-3
• 302-79-4

• 58526-50-4

Reference: [1]Magnetic Resonance in Chemistry,1989,vol. 27,p. 707 - 709

Downstream Synthesis Route 4

• 302-79-4

• 302-79-4

Reference: [1]Journal of the American Chemical Society,1955,vol. 77,p. 4111,4117

* For details of the synthesis route, please refer to the original source to ensure accuracy.