Dapaconazole

• CAS: 1269726-67-1
• Catalog Number: ACM1269726671
• Category: Others
• Molecular Weight: 415.24
• Molecular Formula: C19H15Cl2F3N2O
• Description: Dapaconazole is an antifungal drug candidate. Phase II trials showed that Dapaconazole tosylate is non-inferior to ketoconazole when used at a dose of 20 mg/day for 28 consecutive days for the treatment of PV. Dapaconazole also demonstrated a good safety profile.
• IUPAC Name: 1-(2-(2,4-dichlorophenyl)-2-((4-(trifluoromethyl)benzyl)oxy)ethyl)-1H-imidazole
• Canonical SMILES: FC(C1=CC=C(COC(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)C=C1)(F)F
• InChI: InChI=1S/C19H15Cl2F3N2O/c20-15-5-6-16(17(21)9-15)18(10-26-8-7-25-12-26)27-11-13-1-3-14(4-2-13)19(22,23)24/h1-9,12,18H,10-11H2
• InChI Key: FUAHXHWSMYFWGE-UHFFFAOYSA-N
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: Dapaconazole, as an antifungal agent, inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 μM
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 54.96; H, 3.64; Cl, 17.07; F, 13.73; N, 6.75; O, 3.85
• Exact Mass: 414.0514
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: TBD
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).