Danshensu

• CAS: 76822-21-4
• Catalog Number: ACM76822214
• Category: Inhibitors
• Molecular Weight: 198.17
• Molecular Formula: C9H10O5
• Description: Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.
• Synonyms: (R)-2-Hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid
• IUPAC Name: (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid
• Canonical SMILES: C1=CC(=C(C=C1C[C@H](C(=O)O)O)O)O
• InChI: InChI=1S/C9H10O5/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14/h1-3,8,10-12H,4H2,(H,13,14)/t8-/m1/s1
• InChI Key: PAFLSMZLRSPALU-MRVPVSSYSA-N
• Melting Point: >210 °C (dec.)
• Density: 1.546 g/ml
• Appearance: Light beige solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• pKa: 3.82±0.10
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: PlantsCompositaeHemistepta lyrataPlantsLabiatae

Synthetic Use

Downstream Synthesis Route 1

• 6591-61-3
• 23028-17-3

• 1174681-30-1

Reference: [1]Journal of Natural Products,2009,vol. 72,p. 1379 - 1384

Downstream Synthesis Route 2

• 24461-61-8
• 23028-17-3

• 1174681-32-3

Reference: [1]Chemical and Pharmaceutical Bulletin,2010,vol. 58,p. 394 - 397
[2]Chemical and Pharmaceutical Bulletin,2011,vol. 59,p. 88 - 95
[3]Chemical and Pharmaceutical Bulletin,2012,vol. 60,p. 499 - 507
[4]Fitoterapia,2013,vol. 91,p. 51 - 59
[5]Phytochemistry,2014,vol. 101,p. 91 - 100

Downstream Synthesis Route 3

• 23028-17-3
• 79074-45-6

• 1339946-94-9

Reference: [1]Patent: WO2012/103813,2012,A1 .Location in patent: Page/Page column 18

* For details of the synthesis route, please refer to the original source to ensure accuracy.