Cyclamic acid

• CAS: 100-88-9
• Catalog Number: ACM100889
• Category: Other Products
• Molecular Weight: 179.24
• Molecular Formula: C₆H₁₃NO₃S
• Synonyms: Sucaryl acidxine
• IUPAC Name: Cyclohexylsulfamic acid
• Canonical SMILES: C1CCC(CC1)NS(=O)(=O)O
• InChI: InChI=1S/C6H13NO3S/c8-11(9,10)7-6-4-2-1-3-5-6/h6-7H,1-5H2,(H,8,9,10)
• InChI Key: HCAJEUSONLESMK-UHFFFAOYSA-N
• Melting Point: ~180 °C
• Density: 1.149 g/cm³
• Solubility: Soluble in alcohol, insoluble in oils
• Exact Mass: 179.06161445
• Monoisotopic Mass: 179.06161445
• Odor: Odorless
• Physical State: Solid
• Topological Polar Surface Area: 74.8 Ų

Synthetic Use

Upstream Synthesis Route 1

• 108-91-8

• 100-88-9

Reference: [1]White, Emil H.; Li, Min; Lu, Shanzheng
[Journal of Organic Chemistry, 1992, vol. 57, # 4, p. 1252 - 1258]
[2]Audrieth; Sveda
[Journal of Organic Chemistry, 1944, vol. 9, p. 89,94]
[3]Scott,F.L. et al.
[Journal of the Chemical Society. Perkin transactions I, 1972, p. 2663 - 2666]
[4]Hack, Carolina R. L.; Porciuncula, Larissa; Weber, Andressa C. H.; D'Oca, Caroline R. M.; Russowsky, Dennis; Moura, Jaqueline M.; Pinto, Luiz A. A.; D'Oca, Marcelo G. M.
[Journal of the Brazilian Chemical Society, 2018, vol. 29, # 11, p. 2342 - 2349]

Upstream Synthesis Route 2

• 3173-53-3

• 100-88-9

Reference: [1]Current Patent Assignee: DUPONT DE NEMOURS INC - US2800501, 1954, A

Upstream Synthesis Route 3

• 2211-64-5

• 100-88-9

Reference: [1]Current Patent Assignee: ABBOTT LABORATORIES INC - US2850531, 1955, A
Current Patent Assignee: BAYER AG - DE950369, 1954, C