CAS
76996-27-5 Purity
98%
76996-27-5 Purity
98%
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Coelonin
CAS
82344-82-9
Catalog Number
ACM82344829
Category
Inhibitors
Molecular Weight
242.27
Molecular Formula
C15H14O3
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Specification
Description
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein.
Synonyms
9,10-Dihydro-4-methoxy-2,7-phenanthrenediol
IUPAC Name
4-methoxy-9,10-dihydrophenanthrene-2,7-diol
Canonical SMILES
COC1=CC(=CC2=C1C3=C(CC2)C=C(C=C3)O)O
InChI
InChI=1S/C15H14O3/c1-18-14-8-12(17)7-10-3-2-9-6-11(16)4-5-13(9)15(10)14/h4-8,16-17H,2-3H2,1H3
InChI Key
OPPGAHUCKDKQJR-UHFFFAOYSA-N
Appearance
Solid
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