Chelerythrine

• CAS: 34316-15-9
• Catalog Number: ACM34316159
• Category: Inhibitors
• Molecular Weight: 348.83
• Molecular Formula: C₂₁H₁₈ClNO₄
• Description: Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy.
• Synonyms: Broussonpapyrine; Cheleritrine; Chelerythrin; Chelerythrine chloride; Chelerythrin-Kation; Chelerythrine; Chelerythrin chlorid
• IUPAC Name: 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium
• Canonical SMILES: C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5
• InChI Key: LLEJIEBFSOEYIV-UHFFFAOYSA-N
• Melting Point: 195-205ºC
• EC Number: 251-930-0
• Exact Mass: 383.09200
• Hazard Statements: Xn:Harmful
• Safety Description: S36/37