Caprylic capric triglycerride

• CAS: 65381-09-1
• Catalog Number: ACM65381091-1
• Category: Other Products
• Molecular Weight: 372.54
• Molecular Formula: C₂₁H₄₀O₅
• Synonyms: Caprylic/capric triglyceride, Octanoic/decanoic acid triglyceride, Caprylic acid, capric acid triglyceride, CID93356, EINECS 265-724-3, Decanoic acid, ester with 1,2,3-propanetriol octanoate, 65381-09-1, 97794-26-8
• IUPAC Name: decanoic acid; octanoic acid; propane-1,2,3-triol
• InChI Key: STORWMDPIHOSMF-UHFFFAOYSA-N
• Boiling Point: 456ºC at 760 mmHg
• Flash Point: 142.6ºC
• Density: 0.94-0.96
• Appearance: Transparent or yellowish clear liquid
• Exact Mass: 464.33500
• H-Bond Acceptor: 7
• H-Bond Donor: 5

Case Study

Effect of Caprylic capric triglycerride on the stratum corneum

de Souza Neto, Alicio Vitorino, et al. Life 13.4 (2023): 876.

Natural moisturizing factors (NMFs) include a variety of compounds in the stratum corneum (SC), including urocanic acid (UCA). Ultraviolet (UV) exposure converts trans-UCA of SC to its cis-isomer. Effect of topical skin lotion treatment on UCA isomers of SC exposed to artificial UV stress. Aliquots of skin lotion were applied to delineated areas on the volar forearm of healthy subjects for 2 h, and then the SC was removed by tape stripping. The tape was irradiated in a solar simulator chamber, and UCA isomers in the stripped SC extract were quantified using high-performance liquid chromatography. The levels of both UCA isomers were almost twofold higher in SC treated with the skin lotion. In vivo testing corroborates the UCA data obtained ex vivo, finding an increase in superficial skin hydration with a corresponding decrease in transepidermal water loss(TEWL), which may be caused by the occlusion performed by the emollient lotion containing 15.0% w/w caprylic/capric triglycerides.
When the emollient lotion was applied to the forearm of the subjects, the total UCA concentration (the sum of trans and cis UCA) in the SC samples increased significantly compared to untreated SC. Certain types of emollients are able to form a lipid film on the surface of the skin, reduce TEWL, increase hydration, and my sample contained 15.0% w/w caprylic/capric triglycerides, which is a comparable concentration, an emollient skin occlusive agent. The concentration of both isomers of UCA was almost doubled in SC treated with the emollient lotion. The application of the emollient sample for 2 hours increased the UCA concentration in the outermost layer of the SC. When the cosmetics were used for 30 days, UCA was analyzed as a biomarker of NMF and the results showed an increase of 38.5%.

Encapsulation of dementholized mint flavor using caprylic/capric triglyceride

Ye, Kai, et al. RSC advances 6.87 (2016): 84119-84126.

Dementholized (DP) flavor nanocapsules with/without added mint flavor used caprylic/capric triglyceride (GTCC) as core material and polyurea as shell material. The results showed that the addition of GTCC could significantly reduce the size of nanocapsules and improve the size distribution of nanocapsules. Under the optimized conditions, the obtained DP-GTCC nanocapsules maintained good physical stability, while the DP nanocapsule dispersion physically separated in a very short time. Its average nanocapsule diameter was 82.8 nm and the size distribution was narrow, 0.19. The nanocapsules had a DP flavor loading of up to 16% and an encapsulation efficiency of up to 81%. In addition, the addition of GTCC further improved the stability of the core material with respect to heat dissipation performance. The DP-GTCC nanocapsule dispersion was very stable and showed good transparency in the nanocapsules.
The nanocapsules were prepared by the "interfacial polymerization" method. The surfactant sodium dodecyl sulfate (SDS) was dissolved in water (below its critical micelle concentration) to prepare the aqueous phase. Then, IPDI or a mixture of IPDI and GTCC was dissolved in DP at room temperature to prepare an oil phase. The resulting oil solution was poured into the water phase. The mixture was then emulsified with an ultrasonic device using 2% SDS as an emulsifier in an ice water bath for 30 minutes at a power efficiency of 50%, thereby forming a nanoemulsion. Subsequently, the nanoemulsion was heated in a 35°C water bath for 3 minutes. Then, HMDA (40%) (70%) was diluted and added dropwise to the nanoemulsion to initiate polymerization under magnetic stirring. After 30 minutes, the bath temperature was raised to 55°C, and the reaction was terminated.