Bunamidine hydrochloride

• CAS: 1055-55-6
• Catalog Number: ACM1055556-1
• Category: Others
• Molecular Weight: 419.05
• Molecular Formula: C25H39ClN2O
• Description: Bunamidine is a anti-parasitic drug, which was approved by FDA for the treatment of tapeworms in cats and dogs (Scolaban 400 tablets).
• Synonyms: Bunamidine hydrochloride; Bunamidine HCl; BW62415; BW-62415; BW 62415; Scolaban
• IUPAC Name: 1-Naphthalenecarboximidamide, N,N-dibutyl-4-(hexyloxy)-, monohydrochloride
• Canonical SMILES: N=C(C1=C2C=CC=CC2=C(OCCCCCC)C=C1)N(CCCC)CCCC.[H]Cl
• InChI: InChI=1S/C25H38N2O.ClH/c1-4-7-10-13-20-28-24-17-16-23(21-14-11-12-15-22(21)24)25(26)27(18-8-5-2)19-9-6-3;/h11-12,14-17,26H,4-10,13,18-20H2,1-3H3;1H
• InChI Key: PBYJDHRFPFHVKZ-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >3 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 1055-55-6 (HCl); 3748-77-4 (free base)
• Biological Target: Bunamidine hydrochloride is a veterinary anti-platyhelmintic agent used for Echinococcus granulosus and Taenia hydatigena.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 71.66; H, 9.38; Cl, 8.46; N, 6.69; O, 3.82
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: TBD
• In Vivo Activity: Bunamidine, in the rat heart, caused a dose-dependent decrease in spontaneous heart rate, coronary flow and isometric systolic tension, but increased diastolic tension at 10,000 ng/ml. Bunamidine altered electrical activity by prolonging PR, QRS and QT intervals. It also produced partial heart block and ventricular standstill. Lastly, b unamidine diminished cardiac glycogen, ATP and creatine phosphate and increased tissue content of d-glucose-6-phosphate, l-(-)-glycerol-1-phosphate and lactate. Conversion of phosphorylase b to a was increased.; Reference: Gen Pharmacol. 1978;9(2):101-12. https://pubmed.ncbi.nlm.nih.gov/566235/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).