BRD0639

• CAS: 2760881-74-9
• Catalog Number: ACM2760881749
• Category: Inhibitors
• Molecular Weight: 475.95
• Molecular Formula: C21H22ClN5O4S
• Description: BRD0639 is a potent PRMT5 inhibitor. BRD0639 engages the target in cells, disrupts PRMT5-RIOK1 complexes, and reduces substrate methylation. BRD0639 is a first-in-class PBM-competitive inhibitor that can support studies of PBM-dependent PRMT5 activities and the development of novel PRMT5 inhibitors that selectively target these functions.
• Synonyms: BRD0639; BRD 0639; BRD-0639
• IUPAC Name: (S)-2-(4-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-(N-(2-(pyridin-2-yl)ethyl)sulfamoyl)phenyl)propanamide
• Canonical SMILES: C[C@H](N1C(C=C(Cl)C=N1)=O)C(NC2=CC=C(C)C(S(=O)(NCCC3=NC=CC=C3)=O)=C2)=O
• InChI: InChI=1S/C21H22ClN5O4S/c1-14-6-7-18(26-21(29)15(2)27-20(28)11-16(22)13-24-27)12-19(14)32(30,31)25-10-8-17-5-3-4-9-23-17/h3-7,9,11-13,15,25H,8,10H2,1-2H3,(H,26,29)/t15-/m0/s1
• InChI Key: BXDCFRRDENJUJM-HNNXBMFYSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 2760881-74-9; 2760909-27-9 (R-isomer)
• Biological Target: BRD0639 is a first-in-class inhibitor of the PRMT5-substrate adaptor interaction.
• Drug Formulation: To be determined
• Elemental Analysis: C, 53.00; H, 4.66; Cl, 7.45; N, 14.71; O, 13.45; S, 6.74
• Exact Mass: 475.1081
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: Optimization of the starting hit produced a lead compound, BRD0639, which engages the target in cells, disrupts PRMT5-RIOK1 complexes, and reduces substrate methylation. BRD0639 is a first-in-class PBM-competitive inhibitor that can support studies of PBM-dependent PRMT5 activities and the development of novel PRMT5 inhibitors that selectively target these functions.; Reference: J Med Chem. 2021 Aug 12;64(15):11148-11168. https://pubmed.ncbi.nlm.nih.gov/34342224/
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).