BMS303141

• CAS: 943962-47-8
• Catalog Number: ACM943962478-1
• Category: Inhibitors
• Molecular Weight: 424.30
• Molecular Formula: C19H15Cl2NO4S
• Description: BMS303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.
• Synonyms: BMS303141; BMS-303141; BMS 303141
• IUPAC Name: 3,5-dichloro-2-hydroxy-N-(4-methoxy-[1,1'-biphenyl]-3-yl)benzenesulfonamide
• Canonical SMILES: O=S(C1=CC(Cl)=CC(Cl)=C1O)(NC2=CC(C3=CC=CC=C3)=CC=C2OC)=O
• InChI: InChI=1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3
• InChI Key: SIIPNDKXZOTLEA-UHFFFAOYSA-N
• Solubility: Soluble in DMSO, not in water
• Appearance: White to off-white solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 53.78; H, 3.56; Cl, 16.71; N, 3.30; O, 15.08; S, 7.56
• Exact Mass: 423.00988
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: This study performed polyclonal activation of murine CD8+ T cells in vitro in the presence or absence of the Acly inhibitor BMS303141. This study found that inhibiting Acly during early activation results in decreased expression of early activation markers.; Reference: Cytometry A. 2020 Dec 16. https://pubmed.ncbi.nlm.nih.gov/33325591/
• In Vivo Activity: BMS-303141 also suppressed osteoclast formation in vivo and prevents ovariectomy (OVX)-induced bone loss.; Reference: J Bone Miner Res. 2021 Jun 22. doi: 10.1002/jbmr.4399. https://pubmed.ncbi.nlm.nih.gov/34155695/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).