Structure

Angelicin

CAS
523-50-2
Catalog Number
ACM523502
Category
Inhibitors
Molecular Weight
186.16
Molecular Formula
C11H6O3

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Specification

Description
Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.IC50 value: 49.56 μM (cellular cytotoxicity); 5.39 μg/ml (28.95 μM) (against MHV-68)Target:In vitro: In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells . Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways .In vivo:
Canonical SMILES
O=C1C=CC2=CC=C(OC=C3)C3=C2O1
Appearance
Solid
Storage
Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
Shipping
Can be shipped at room temperature, where not in use may vary.
Source
PlantsLeguminosaePsoralea corylifolia L.

Upstream Synthesis Route 1

  • 59292-71-6
  • 127-09-3
  • 108-24-7
  • 523-50-2

Reference: [1]Rasayanam,1936,vol. 1,p. 1,14

Upstream Synthesis Route 2

  • 59292-71-6
  • 523-50-2

Reference: [1]Rasayanam,1936,vol. 1,p. 1,14

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