Amrubicin

• CAS: 110267-81-7
• Catalog Number: ACM110267817
• Category: Inhibitors
• Molecular Weight: 483.47
• Molecular Formula: C₂₅H₂₅NO₉
• Description: Amrubicin (SM-5887) is a DNA topoisomerase II inhibitor, used for the research of cancer.
• Synonyms: (7S,9S)-9-Acetyl-9-amino-7-[(2-deoxy--D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione;(7S)-9β-Amino-9-acetyl-7β-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxynaphthacene-5,12-dione;(7S,9S)-9-Acetyl-9-amino-7-(2-deoxy-β-D-erythro-pentopyranosyloxy)-6,11-dihydroxy-5,7,8,9,10,12-hexahydro-5,12-naphthacenedione;(7S,9S)-9-Amino-9-acetyl-7-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxynaphthacene-5,12-dione;Amurubicin;5,12-Naphthacenedione,9-acetyl-9-aMino-7-(2-deoxy-b-D-erythro-pentopyranosyl)oxy-7,8,9,10-tetrahydro-6,11-dihydroxy-,(7S,9S)-
• Melting Point: 172-1740C

Custom Q&A

What is the molecular formula of Amrubicin?

The molecular formula of Amrubicin is C25H25NO9.

What is the molecular weight of Amrubicin?

The molecular weight of Amrubicin is 483.5 g/mol.

What is Amrubicin used for in terms of cancer treatment?

Amrubicin is used in the treatment of cancer, particularly lung cancer, as a specific inhibitor of topoisomerase II.

How is Amrubicin described in terms of its role and chemical structure?

Amrubicin is described as a topoisomerase II inhibitor, an antineoplastic agent, and a prodrug. It is a quinone, a member of tetracenes, a methyl ketone, an anthracycline antibiotic, and a primary amino compound.

When was Amrubicin first created and when was it last modified?

Amrubicin was first created in August 2005 and was last modified in December 2023.

What is the IUPAC name of Amrubicin?

The IUPAC name of Amrubicin is (7S,9S)-9-acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxyoxan-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione.

What is the InChIKey of Amrubicin?

The InChIKey of Amrubicin is VJZITPJGSQKZMX-XDPRQOKASA-N.

What is the Canonical SMILES of Amrubicin?

The Canonical SMILES of Amrubicin is CC(=O)C1(CC(C2=C(C1)C(=C3C(=C2O)C(=O)C4=CC=CC=C4C3=O)O)OC5CC(C(CO5)O)O)N.

What are some synonyms for Amrubicin?

Some synonyms for Amrubicin include Amrubicin(SM-5887), 93N13LB4Z2, and Amrubicin [INN].

What is the ChEBI description of Amrubicin?

The ChEBI description of Amrubicin states that it is a synthetic anthracycline antibiotic currently in development for the treatment of small cell lung cancer.