5-Aminosalicylic acid

• CAS: 89-57-6
• Catalog Number: ACM89576-1
• Category: Amino Acids
• Molecular Weight: 153.14
• Molecular Formula: H2NC6H3-2-(OH)CO2H
• Description: 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
• Synonyms: 5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine
• IUPAC Name: 5-Amino-2-hydroxybenzoic acid
• Canonical SMILES: Nc1ccc(O)c(c1)C(O)=O
• InChI: 1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
• InChI Key: KBOPZPXVLCULAV-UHFFFAOYSA-N
• Boiling Point: 276.03 °C
• Melting Point: 275-280 ℃(dec.) (lit.)
• Flash Point: 279-281 °C
• Density: 1.3585 g/cm³
• Solubility: Insoluble in ethanol
• Appearance: Solid
• Application: 5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.
• Storage: 2-8 °C
• Assay: 0.95
• Beilstein: 2090421
• Complexity: 160
• EC Number: 201-919-1
• Exact Mass: 153.042593085
• Form: powder with small lumps
• Gene Information: human ALOX5(240), PPARG(5468), PTGS1(5742), PTGS2(5743)
• Hazard Statements: Xi
• MDL Number: MFCD00007877
• Monoisotopic Mass: 153.042593085
• NACRES: NA.22
• PubChem ID: 24891301
• Quality Level: 200
• Reaction Suitability: reaction type: solution phase peptide synthesis
• Refractive Index: 1.5500
• Safety Description: 26-36-24/25
• Storage Temperature: 2-8℃
• Supplemental Hazard Statements: H315-H319-H335
• Symbol: GHS07
• Topological Polar Surface Area: 83.6 Ų

Synthetic Use

Downstream Synthesis Route 1

• 67-56-1
• 89-57-6

• 42753-75-3

Reference: [1] Journal of Organic Chemistry, 2011, vol. 76, # 15, p. 5873 - 5881

Downstream Synthesis Route 2

• 7664-93-9
• 89-57-6

• 42753-75-3

Reference: [1] Patent: US4933330, 1990, A,

Downstream Synthesis Route 3

• 89-57-6

• 345-16-4

Reference: [1] Tetrahedron, 1996, vol. 52, # 1, p. 23 - 36
[2] Journal of Fluorine Chemistry, 1991, vol. 51, # 2, p. 299 - 304

Downstream Synthesis Route 4

• 67-56-1
• 89-57-6

• 42753-75-3

Reference: [1]Journal of Organic Chemistry,2011,vol. 76,p. 5873 - 5881

* For details of the synthesis route, please refer to the original source to ensure accuracy.