ALC-0159

• CAS: 1849616-42-7
• Catalog Number: ACM1849616427-1
• Category: Others
• Molecular Weight: 2450.00
• Molecular Formula: (C2H4O)nC31H63NO2
• Description: ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid), specifically, it is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). It is a non-ionic surfactant by its nature. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine that contains the active ingredient tozinameran.
• Synonyms: ALC-0159; ALC 0159; ALC0159
• IUPAC Name: 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
• Canonical SMILES: CCCCCCCCCCCCCCN(CCCCCCCCCCCCCC)C(COCCOC)=O
• InChI: InChI=1S/C33H67NO3/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-34(33(35)32-37-31-30-36-3)29-27-25-23-21-19-17-15-13-11-9-7-5-2/h4-32H2,1-3H3
• InChI Key: BPWFJNQUTKVHIR-UHFFFAOYSA-N
• Solubility: To be determined
• Appearance: Solid
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: ALC-0159 is a polyethylene glycol (PEG) lipid conjugate that could be used as vaccine excipient.
• Drug Formulation: To be determined
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. The LNPs in the Pfizer-BioNTech COVID-19 vaccine contain low levels (<2 mol %) of ALC-0159, which contributes to nanoparticle stabilization by a steric mechanism through its poly(ethylene glycol) (PEG) moiety. Considering their low ALC-0159 content, LNPs in the Pfizer-BioNTech COVID-19 vaccine most likely display a weak steric barrier of PEG.; Reference: Mol Ther. 2021 Mar 3;29(3):898-900. https://pubmed.ncbi.nlm.nih.gov/33571463/
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).