Ablukast

• CAS: 96566-25-5
• Catalog Number: ACM96566255-1
• Category: Antagonists
• Molecular Weight: 498.57
• Molecular Formula: C28H34O8
• Description: Ablukast is a leuktriene receptor antagonist that acts as an anti-asthmatic.
• Synonyms: Ablukast; Ro 23-3544; Ro-23-3544; Ro23-3544; Ro 233544; Ro-233544; Ro233544; Ro 23-3544/000
• IUPAC Name: 2H-1-Benzopyran-2-carboxylic acid, 6-acetyl-7-((5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentyl)oxy)-3,4-dihydro-, (+-)-
• Canonical SMILES: O=C(C1CCC2=CC(C(C)=O)=C(OCCCCCOC3=CC=C(C(C)=O)C(O)=C3CCC)C=C2O1)O
• InChI: InChI=1S/C28H34O8/c1-4-8-21-23(12-10-20(17(2)29)27(21)31)34-13-6-5-7-14-35-26-16-25-19(15-22(26)18(3)30)9-11-24(36-25)28(32)33/h10,12,15-16,24,31H,4-9,11,13-14H2,1-3H3,(H,32,33)
• InChI Key: FGGYJWZYDAROFF-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 96565-55-8 (sodium); 96566-25-5 (free acid); 96686-71-4 (S-isomer); 96686-73-6 (R-isomer)
• Biological Target: Ablukast (Ro 23-3544) is a specific and active leukotriene receptor antagonist that effectively reduces LTC4- and antigen-induced bronchoconstriction
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 67.45; H, 6.87; O, 25.67
• Exact Mass: 498.2254
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: TBD
• In Vivo Activity: In this study, the dose-response curves of N-methyl LTC4 (NMLTC4), the nonmetabolizable LTC4 analogue, and the peptidoleukotrienes (LTC4, LTD4, and LTE4) were obtained in the absence and presence of the leukotriene antagonist Ro 23-3544 in cannulated frogs. The NMLTC4- and LTC4-induced hypotensive effects were antagonized by Ro 23-3544. Ro 23-3544 also antagonized the effects induced by high doses of LTD4 and LTE4. Ro 23-3544 had no effect on duration of response and did not affect heart rate responses to LTC4 at low dose of the antagonist. The data suggest that receptors that preferentially bind LTC4 in bullfrog vascular smooth muscle regulate the hypotensive effect and that they can be antagonized by Ro 23-3544.; Reference: Can J Physiol Pharmacol. 1995 Mar;73(3):383-9. https://pubmed.ncbi.nlm.nih.gov/7648518/
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).