6-Nitro-3,4-dihydro-1H-quinolin-2-one

• CAS: 22246-16-8
• Catalog Number: ACM22246168
• Category: Other Products
• Molecular Weight: 192.17
• Molecular Formula: C9H8N2O3
• Synonyms: 3,4-Dihydro-6-nitro-2(1H)-quinolinone;6-Nitro-3,4-dihydro-1H-quinolin-2-one
• IUPAC Name: 6-nitro-3,4-dihydro-1H-quinolin-2-one
• Canonical SMILES: C1CC(=O)NC2=C1C=C(C=C2)[N+](=O)[O-]
• InChI Key: NQMSVHWAVMTBHK-UHFFFAOYSA-N
• Boiling Point: 420.3ºC at 760mmHg
• Melting Point: 201-202ºC
• Flash Point: 208ºC
• Density: 1.366g/cm³
• Appearance: Off-white to yellowish brown solid
• Exact Mass: 192.05300
• Hazard Statements: T: Toxic
• H-Bond Acceptor: 3
• H-Bond Donor: 1

Synthetic Use

Upstream Synthesis Route 1

• 553-03-7

• 22246-16-8

Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4606 - 4609

Upstream Synthesis Route 2

• 553-03-7

• 22246-16-8

Reference: [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 4606 - 4609

Downstream Synthesis Route 1

• 22246-16-8

• 22246-13-5

Reference: [1] Patent: WO2015/38417, 2015, A1, . Location in patent: Page/Page column 90; 91

Downstream Synthesis Route 2

• 22246-16-8

• 29969-57-1

Reference: [1] Heterocycles, 1998, vol. 48, # 12, p. 2637 - 2641
[2] Patent: US2007/27184, 2007, A1, . Location in patent: Page/Page column 18; 25
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 20, p. 5270 - 5274
[4] Patent: KR101576386, 2015, B1, . Location in patent: Paragraph 0190; 0193-0194

Downstream Synthesis Route 3

• 22246-16-8

• 22246-13-5

Reference: [1]Patent: WO2020/28461,2020,A1 .Location in patent: Paragraph 00177-

Downstream Synthesis Route 4

• 22246-16-8

• 296759-27-8

Reference: [1]Proceedings of the Imperial Academy (Tokyo),1939,vol. 15,p. 148,153
Chemisches Zentralblatt,1939,vol. 110,p. 3089

* For details of the synthesis route, please refer to the original source to ensure accuracy.