2-Amino-7-bromoquinazoline

• CAS: 190274-15-8
• Catalog Number: ACM190274158
• Category: Other Products
• Molecular Weight: 224.05734
• Molecular Formula: C8H6BrN3
• Synonyms: 2-AMINO-7-BROMOQUINAZOLINE, 7-bromoquinazolin-2-amine, 190274-15-8, SureCN1741867, 2-Quinazolinamine,7-bromo-, ACMC-1C9P4, 7-Bromo-quinazolin-2-ylamine, CTK4E0350, MolPort-020-003-715, ANW-23481, ZINC14982018, AKOS015897193, AG-E-38915, RP27507, AK-30515, BP-20117, KB-68118, BB 0261215, I08-671, 2-Amino-7-bromoquinazoline;7-Bromoquinazolin-2-amine
• IUPAC Name: 7-bromoquinazolin-2-amine
• Canonical SMILES: C1=CC2=CN=C(N=C2C=C1Br)N
• InChI Key: CFUQBLOSOCYEIG-UHFFFAOYSA-N
• Boiling Point: 425.339ºC at 760 mmHg
• Flash Point: 211.038ºC
• Density: 1.744g/cm³
• Exact Mass: 222.97500
• H-Bond Acceptor: 3
• H-Bond Donor: 1

Synthetic Use

Upstream Synthesis Route 1

• 2733561-63-0

• 190274-15-8

Reference: [1]Current Patent Assignee: AMGEN INC - WO2010/83246, 2010, A1
Location in patent: Page/Page column 55

Downstream Synthesis Route 1

• 24424-99-5
• 190274-15-8

• 1820683-11-1

Reference: [1]Taylor, Nicholas J.; Emer, Enrico; Preshlock, Sean; Schedler, Michael; Tredwell, Matthew; Verhoog, Stefan; Mercier, Joel; Genicot, Christophe; Gouverneur, Véronique
[Journal of the American Chemical Society, 2017, vol. 139, # 24, p. 8267 - 8276]
[2]Acton, John J.; Adpressa, Donovon; Ardolino, Michael J.; Bennett, David Jonathan; Chau, Ryan W.; Ciaccio, Paul J.; Dimauro, Erin F.; Faltus, Robert; Fell, Matthew J.; Fuller, Peter H.; Gulati, Anmol; Hegde, Laxminarayan G.; Johnson, Rebecca E.; Kattar, Solomon D.; Kennedy, Matthew E.; Keylor, Mitchell H.; Lesburg, Charles A.; Lin, Shishi; Liu, Ping; Margrey, Kaila A.; McMinn, Spencer E.; Morriello, Gregori J.; Neelamkavil, Santhosh; Nogle, Lisa; Otte, Karin M.; Palte, Rachel L.; Piesvaux, Jennifer; Pio, Barbara; Poremba, Kelsey E.; Simov, Vladimir; Su, Jing; Wood, Harold B.; Woodhouse, Janice D.; Xiong, Tina; Yan, Xin; Zarate, Cayetana
[Journal of Medicinal Chemistry, 2022, vol. 65, # 1, p. 838 - 856]
[3]Current Patent Assignee: ALESTA THERAPEUTICS; BLACK BELT TX - WO2021/165346, 2021, A1
Location in patent: Paragraph 201

* For details of the synthesis route, please refer to the original source to ensure accuracy.