Filgotinib(glpg0634)

• CAS: 1206161-97-8
• Catalog Number: ACM1206161978
• Category: Other Products
• Molecular Weight: 0
• Molecular Formula: C₂₁H₂₃N₅O₃S
• Synonyms: GPLG0634;GLPG0634;SYN1158;CyclopropanecarboxaMide, N-[5-[4-[(1,1-dioxido-4-thioMorpholinyl)Methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-;GLPG0634 (analog);N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide;Filgotinib (GLPG0634);N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamideFilgotinib (GLPG0634)

Custom Q&A

What is the molecular formula of filgotinib?

The molecular formula of filgotinib is C21H23N5O3S.

What is the molecular weight of filgotinib?

The molecular weight of filgotinib is 425.5 g/mol.

When was filgotinib created?

Filgotinib was created on January 10, 2011.

What is the role of JAK1 in the body?

JAK1 plays a key role in the signaling and activity of many cytokines and growth factors and is often dysregulated in autoimmune and inflammatory diseases.

What is the primary target of filgotinib?

The primary target of filgotinib is the tyrosine kinase Janus kinase 1 (JAK1).

How does filgotinib work in the body?

Filgotinib specifically targets and inhibits the phosphorylation of JAK1, which interferes with JAK/STAT-dependent signaling. This prevents cytokine signaling and activity in inflammatory and immune-mediated processes, leading to a decrease in inflammation.

What is the IUPAC name of filgotinib?

The IUPAC name of filgotinib is N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide.

What is the InChIKey of filgotinib?

The InChIKey of filgotinib is RIJLVEAXPNLDTC-UHFFFAOYSA-N.

What is the Canonical SMILES of filgotinib?

The Canonical SMILES of filgotinib is C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5.

What is the CAS number of filgotinib?

The CAS number of filgotinib is 1206161-97-8.