Domperidone

• CAS: 57808-66-9
• Catalog Number: ACM57808669
• Category: Main Products
• Molecular Weight: 425.91
• Molecular Formula: C₂₂H₂₄ClN₅O₂
• Synonyms: 2h-benzimidazol-2-one,1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1h-benzi;5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidaz;kw-5338;midazol-1-yl)propyl)-4-piperidinyl)-;DOMPERIDONE;4-(5-chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine;ALPHA-[2-(DIISOPROPYLAMINO)ETHYL]-ALPHA-PHENYL-2-PYRIDINE-ACETAMIDE;5-CHLORO-1-[1-[3-(2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOL-1-YL)PROPYL]-4-PIPERIDINYL]-1,3-DIHYDRO-2H-BENZ-IMIDAZOL-2-ONE
• IUPAC Name: Domperidone
• Melting Point: 240-244°C
• Density: 1.341 g/cm³
• Appearance: solid
• Exact Mass: 425.16200
• Hazard Statements: Xn
• Safety Description: 26-36
• Stability: Stable. Incompatible with strong oxidizing agents.
• Supplemental Hazard Statements: H361-H360
• Symbol: GHS08
• WGK Germany: 3

Case Study

Domperidone Used for Ultra-Fast Delivery in Electrospun Nanofiber Membranes Preparation

Ardalkar S, et al. Journal of Drug Delivery Science and Technology, 2024, 95, 105645.

The preparation of electrospun nanofiber membranes for the ultra-fast delivery of Domperidone (10 mg) involves a precise formulation process to ensure uniform drug dispersion and optimal release characteristics. Polyvinyl alcohol (PVA) is dissolved in a water-DMSO (4:1) mixture and stirred for 2 hours. The Domperidone is then incorporated into the PVA solution, followed by another hour of stirring to form a homogeneous mixture. A blank solution, prepared without the drug, serves as a control.
The electrospinning process is carried out using laboratory-scale equipment, with a grounded metal electrode and polyethylene target sheet to collect the nanofibers. The solution is fed into a 100 µL syringe attached to a 0.52 mm metal needle, with the feed rate varying between 0.125-0.375 mL/min, and voltage settings ranging from 11-15 kV. The distance from the syringe tip to the collector is maintained at 10 cm. Nanofibers are collected on a polyethylene mesh-covered collector connected to the grounded electrode.
The resulting electrospun membranes are stored in a desiccator for further characterization. In addition, cast films are prepared with optimized drug-polymer concentrations, following a similar preparation process. These films are dried in a vacuum chamber for 72 hours under controlled environmental conditions (25 ± 2°C and 40 ± 5% relative humidity).

Custom Q&A

What is the molecular formula of domperidone?

The molecular formula of domperidone is C22H24ClN5O2.

What is the molecular weight of domperidone?

The molecular weight of domperidone is 425.9 g/mol.

What is the IUPAC name of domperidone?

The IUPAC name of domperidone is 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one.

What is the InChIKey of domperidone?

The InChIKey of domperidone is FGXWKSZFVQUSTL-UHFFFAOYSA-N.

What are the synonyms of domperidone?

The synonyms of domperidone are Motilium, Domperidona, and Domperidonum.

What is the role of domperidone?

Domperidone has the role of being an antiemetic and a dopaminergic antagonist.

What receptors does domperidone block?

Domperidone is a specific blocker of dopamine receptors.

What are the uses of domperidone?

Domperidone is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism.

How does domperidone work?

Domperidone binds to dopamine receptor D2 (D2R) expressed by peripheral neurons, inhibiting dopamine binding and D2R-mediated signaling. This helps relieve various gastrointestinal symptoms such as nausea and vomiting.

What are the identifiers for domperidone?

The CAS number for domperidone is 57808-66-9. Other identifiers include CAS Common Chemistry, ChemIDplus, DrugBank, DTP/NCI, EPA DSSTox, European Chemicals Agency (ECHA), FDA Global Substance Registration System (GSRS), and Human Metabolome Database (HMDB).