Chlormadinone acetate

CAS

302-22-7

Catalog Number

ACM302227

Category

Steroidal Compounds

Molecular Weight

404.93

Molecular Formula

C₂₃H₂₉ClO₄

MSDS COA Spec Sheet

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Specification

Synonyms

6-chloro-17-hydroxypregna-4,6-diene-3,20-dione acetate; Retex; rs1280; Lormin; Natrol; chlormadinone; Verton; 17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione; ST 155; CMA; Cero; MATROL; 6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate,Gestafortin,Matrol; 6-Chloro-6-dehydro-17α-acetoxyprogesterone;

IUPAC Name

Chlormadinone acetate

Boiling Point

512.5ºC at 760mmHg

Melting Point

212ºC

Flash Point

172.5ºC

Density

1.23g/cm³

Appearance

crystalline solid

Exact Mass

404.17500

Hazard Statements

T: Toxic;

Safety Description

53-22-36/37/39-45

What is the molecular formula of chlormadinone acetate?

The molecular formula of chlormadinone acetate is C23H29ClO4.

What is the molecular weight of chlormadinone acetate?

The molecular weight of chlormadinone acetate is 404.9 g/mol.

When was chlormadinone acetate first synthesized?

Chlormadinone acetate was first synthesized in 1961.

Why was the use of chlormadinone acetate in the US discontinued?

The use of chlormadinone acetate in the US was discontinued because it was associated with the development of mammary tumors in dogs.

What are the progesterone receptor (PR) agonistic effects of chlormadinone acetate?

Chlormadinone acetate binds to progesterone receptors, inducing the expression of progesterone-responsive genes.

What are the antiandrogenic effects of chlormadinone acetate?

Chlormadinone acetate acts as a partial antagonist of the androgen receptor (AR), blocking its activity in target organs and reducing androgen production and signaling.

How does chlormadinone acetate suppress gonadotropin secretion?

Chlormadinone acetate suppresses gonadotropin secretion through negative feedback on the hypothalamus-pituitary system, preventing ovarian and adrenal androgen production.

What is the IUPAC name of chlormadinone acetate?

The IUPAC name of chlormadinone acetate is [(8R,9S,10R,13S,14S,17R)-17-acetyl-6-chloro-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate.

What is the InChIKey of chlormadinone acetate?

The InChIKey of chlormadinone acetate is QMBJSIBWORFWQT-DFXBJWIESA-N.

What is the CAS number of chlormadinone acetate?

The CAS number of chlormadinone acetate is 302-22-7.