XI-011 HCl

CAS

59474-01-0

Catalog Number

ACM59474010-1

Category

Inhibitors

Molecular Weight

316.85

Molecular Formula

C17H17ClN2S

MSDS COA Spec Sheet

If you have any other questions or need other size, please get a quote.

Specification

Description

XI-011 (NSC146109), a small-molecule inhibitor of MDMX, showed robust anti-proliferation activity against several cervical cancer cell lines. XI-011 promoted apoptosis of cervical cancer cells via stabilizing p53 and activating its transcription activity. Moreover, XI-011 inhibited the growth of xenograft tumor in HeLa tumor-bearing mice, as well as enhanced the cytotoxic activity of cisplatin both in vitro and in vivo.

Synonyms

XI-011 HCl; XI-011 hydrochloride; XI-011; XI011; XI011; NSC 146109 HCl; NSC146109; NSC146109

IUPAC Name

Carbamimidothioic acid, (10-methyl-9-anthracenyl)methyl ester, monohydrochloride

Canonical SMILES

NC(SCC1=C2C=CC=CC2=C(C)C3=CC=CC=C13)=N.[H]Cl

InChI

InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H

InChI Key

VIBMUYOXJUCEMA-UHFFFAOYSA-N

Solubility

To be determined

Appearance

Solid powder

Shelf Life

>2 years if stored properly

Storage

Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).

Alternative CAS

740031-90-7 (free base); 59474-01-0 (HCl)

Drug Formulation

To be determined

Elemental Analysis

C, 64.44; H, 5.41; Cl, 11.19; N, 8.84; S, 10.12

HS Tariff Code

2934.99.9001

Shipping

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Stock Solution Storage

0-4 °C for short term (days to weeks), or -20 °C for long term (months).