1-Trifluoroacetyl piperidine

CAS

340-07-8

Catalog Number

ACM340078

Category

Other Products

Molecular Weight

181.1556096

Molecular Formula

C₇H₁₀F₃NO

MSDS COA Spec Sheet

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Specification

Synonyms

1-Trifluoroacetyl piperidine, 683035_ALDRICH, 340-07-8

IUPAC Name

2,2,2-trifluoro-1-piperidin-1-ylethanone

Canonical SMILES

C1CCN(CC1)C(=O)C(F)(F)F

InChI Key

BCJUMGSHTLYECD-UHFFFAOYSA-N

Boiling Point

247.5ºC at 760 mmHg

Flash Point

77ºC

Density

1.226 g/mL at 25ºC

Appearance

light yellow oil

Exact Mass

181.07100

Hazard Statements

T: Toxic;

H-Bond Acceptor

H-Bond Donor

Safety Description

45-61

Upstream Synthesis Route 1

110-89-4
383-63-1

340-07-8

Reference: [1]Sammelsont, Robert E.; Casida, John E.
[Journal of Organic Chemistry, 2003, vol. 68, # 21, p. 8075 - 8079]
[2]Current Patent Assignee: THE KALYANI GROUP - WO2021/240331, 2021, A1
Location in patent: Page/Page column 8
[3]Laduron, Frederic; Nyns, Claire; Janousek, Zdenek; Viehe, Heinz G.
[Advanced Synthesis and Catalysis, 1997, vol. 339, # 8, p. 697 - 707]
[4]Gómez, Antonio Bermejo; Cortés González, Miguel A.; Lübcke, Marvin; Johansson, Magnus J.; Halldin, Christer; Szabó, Kálmán J.; Schou, Magnus
[Chemical Communications, 2016, vol. 52, # 97, p. 13963 - 13966]
[5]Joullie
[Journal of the American Chemical Society, 1955, vol. 77, p. 6662]

Upstream Synthesis Route 2

110-89-4
407-25-0

340-07-8

Reference: [1]Schenck, Hilary A.; Lenkowski, Paul W.; Choudhury-Mukherjee, Indrani; Ko, Seong-Hoon; Stables, James P.; Patel, Manoj K.; Brown, Milton L.
[Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 979 - 993]

Downstream Synthesis Route 1

340-07-8
38480-28-3

2557-70-2

Reference: [1] Angewandte Chemie - International Edition, 2013, vol. 52, # 52, p. 14191 - 14195[2] Angew. Chem., 2013, vol. 125, # 52, p. 14441 - 14445,5

Downstream Synthesis Route 2

340-07-8
591-17-3

1736-06-7

Reference: [1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 979 - 993
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 52, p. 14191 - 14195[3] Angew. Chem., 2013, vol. 125, # 52, p. 14441 - 14445,5

Downstream Synthesis Route 3

340-07-8
108-37-2

321-31-3

Reference: [1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 979 - 993

* For details of the synthesis route, please refer to the original source to ensure accuracy.