N-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

CAS

151838-62-9

Catalog Number

ACM151838629

Category

Other Products

Molecular Weight

277.32

Molecular Formula

C₁₅H₁₉NO₄

MSDS COA Spec Sheet

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Specification

Synonyms

2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID;N-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;(RS)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-BOC protected;2,3(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-,

IUPAC Name

2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

InChI Key

HFPVZPNLMJDJFB-UHFFFAOYSA-N

Boiling Point

437.6ºC at 760mmHg

Melting Point

125-126ºC

Flash Point

218.5ºC

Density

1.222g/cm³

Exact Mass

277.13100

Hazard Statements

Xi: Irritant;

H-Bond Acceptor

H-Bond Donor

Upstream Synthesis Route 1

24424-99-5
41994-51-8

151838-62-9

Reference: [1] Organic Letters, 1999, vol. 1, # 4, p. 667 - 670
[2] European Journal of Medicinal Chemistry, 2002, vol. 37, # 5, p. 379 - 389
[3] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 10, p. 1289 - 1292
[4] Patent: EP1857444, 2007, A1, . Location in patent: Page/Page column 26
[5] European Journal of Medicinal Chemistry, 2016, vol. 114, p. 345 - 364

Upstream Synthesis Route 2

67123-97-1
24424-99-5

151838-62-9

Reference: [1] Tetrahedron Letters, 1996, vol. 37, # 40, p. 7205 - 7208
[2] Medicinal Chemistry, 2010, vol. 6, # 6, p. 355 - 373
[3] Patent: US2008/255188, 2008, A1, . Location in patent: Page/Page column 10