Polymyxin b sulfate salt

CAS

1405-20-5

Catalog Number

ACM1405205

Category

Main Products

Molecular Weight

1385.61

Molecular Formula

C₅₅H₉₆N₁₆O₁₃·₂H2SO₄

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Specification

Synonyms

PolymyxineBsulfate; MASTIMYXIN; POLYMYXIN B; POLYMYXIN B (PMB); POLYMIXIN B SULFATE; Polymyxin B Sulfate; APPLISORB; PolymyxinBSulfate(sterile,non-sterile); AEROSPORIN; POLYMIXIN B SULPHATE; MYP SUPPLEMENT;

IUPAC Name

Polymyxin B sulfate

Boiling Point

1651ºC at 760 mmHg

Flash Point

952.3ºC

Appearance

White crystalline powder

Exact Mass

1300.72000

Hazard Statements

Xn: Harmful;

Packing Group

III

Safety Description

S22-S24/25

WGK Germany

Determination of Neomycin Sulfate and Polymyxin B Sulfate Simultaneously

Srisom, Piyaporn, et al. Journal of pharmaceutical and biomedical analysis, 2007, 43(3), 1013-1018.

A quick, cheap capillary electrophoresis (CE) coupled with indirect UV detection was invented for simultaneous neomycin sulfate and polymyxin B sulfate detection in pharmaceutical formulations.
Preparation of Standard Solutions
New stock standard solutions of neomycin sulfate and polymyxin B sulfate were prepared one by one by dissolving just 20 mg of each standard in a very small volume of deionised water and diluted to 10 mL at that point. Analyse of neomycin sulfate and polymyxin B sulfate was done by mixing specific volumes of stock solutions, and then reducing with deionised water.
Assay Method
This separation process used a fused silica capillary of inner diameter 50 m and total length 27 cm at applied voltage of 6 kV. The running buffer was 15 mM phosphate solution (pH 5.0) in 40 mM N-(4-hydroxy-phenyl)acetamide and 50 mM TTAB. 280 nm wavelength for detection. The quantitative results were confirmed using method reproducibility tests with relative standard deviation less than 0.4% for migration time and 2.4% for corrected peak area. The accuracy was measured by mixing standards into eye-ear solutions; recoveries of neomycin sulfate and polymyxin B sulfate were 97.44% to 103.18%, and 96.85% to 101.68%, respectively. The linear ranges for neomycin sulfate and polymyxin B sulfate were 17-682 g/mL and 24-608 g/mL, respectively, and the r2 was higher than 0.999.

Antagonism of Polymyxin B Sulfate-Induced Vibrio Qinghaiensis Q67

Fan, Ye, et al. RSC advances, 2017, 7(10), 6080-6088.

Input with a single pesticide (imidacloprid, IMI), two ionic liquids (ILs)([hmim]Br and [hmim]Cl) and two antibiotics (chloramphenicol, CHL and polymyxin B sulfate, POL) as mixture ingredients, four ternary mixture systems ([hmim]Br-IMI-CHL, [hmim]Cl-IMI-CHL, [hmim]Br-IMI-POL and [hmim]Cl-IMI-POL) were built. The time-dependent toxicity of these chemicals and 20 ternary mixture rays and 10 quaternary mixture rays to V qinghaiensis was determined.
Results indicated that the toxicity of IMI remains constant over time, while the toxicities of both ionic liquids decrease and the toxicities of the antibiotics increase as time progresses. The toxicity of both ternary and quaternary mixture rays remains largely unchanged over time, showing no time-dependence in overall mixture toxicity. However, the toxicological interactions of the mixtures vary with different exposure times.
The ternary mixture rays in the [hmim]Br-IMI-CHL and [hmim]Cl-IMI-CHL systems exhibit nearly additive effects, whereas most rays in the [hmim]Br-IMI-POL and [hmim]Cl-IMI-POL systems demonstrate antagonism, which is influenced by the duration of exposure. The toxicological interactions among the various rays in the quaternary mixture systems confirm that POL is a significant factor contributing to the observed time-dependent antagonism.