CGS20625

CAS

111205-55-1

Catalog Number

ACM111205551-1

Category

Others

Molecular Weight

309.37

Molecular Formula

C18H19N3O2

MSDS COA Spec Sheet

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Specification

Description

CGS-20625 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It produces anxiolytic and anticonvulsant effects, but with no sedative effects even at high doses, and no significant muscle relaxant effects. It is orally active in humans, but with relatively low bioavailability. CGS-20625 is a positive allosteric modulator at several GABAA receptors types. Due to its alicyclic moiety potency at γ1 subunit, containing receptor types is more pronounced for CGS-20625 compared to benzodiazepines. γ1 subunits are expressed at higher levels in the central amygdala.

Synonyms

CGS20625; CGS-20625; CGS 20625

IUPAC Name

Cyclohepta(b)pyrazolo(3,4-d)pyridin-3(2H)-one, 5,6,7,8,9,10-hexahydro-2-(4-methoxyphenyl)-

Canonical SMILES

O=C1N(C2=CC=C(OC)C=C2)N=C3C(CCCCC4)=C4NC=C31

InChI

InChI=1S/C18H19N3O2/c1-23-13-9-7-12(8-10-13)21-18(22)15-11-19-16-6-4-2-3-5-14(16)17(15)20-21/h7-11,19H,2-6H2,1H3

InChI Key

XRUUVUYJUULCBQ-UHFFFAOYSA-N

Solubility

Soluble in DMSO

Appearance

Solid powder

Shelf Life

>2 years if stored properly

Storage

Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).

Drug Formulation

This drug may be formulated in DMSO

Elemental Analysis

C, 69.88; H, 6.19; N, 13.58; O, 10.34

Exact Mass

309.1477

HS Tariff Code

2934.99.9001

Shipping

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Stock Solution Storage

0-4 °C for short term (days to weeks), or -20 °C for long term (months).