1-Boc-3-methoxycarbonylmethyleneazetidine

CAS

1105662-87-0

Catalog Number

ACM1105662870

Category

Other Products

Molecular Weight

227.258

Molecular Formula

C₁₁H₁₇NO₄

MSDS COA Spec Sheet

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Specification

Synonyms

1105662-87-0, tert-Butyl 3-(2-methoxy-2-oxoethylidene)azetidine-1-carboxylate, 1-Boc-3-methoxycarbonylmethylene-azetidine, 1-Boc-3-methoxycarbonylmethyleneazetidine, SureCN428501, CTK8C0377, ANW-64580, AKOS015837064, AM90645, PB13590, RP07434, AK103682, KB-60947, AB1011653, FT-0684764, Y7042, C-8659, tert-butyl 3-(2-methoxy-2-oxo-ethylidene)azetidine-1-carboxylate, 1-AZETIDINECARBOXYLIC ACID, 3-(2-METHOXY-2-OXOETHYLIDENE)-, 1,1-DIMETHYLETHYL ESTER

IUPAC Name

tert-butyl 3-(2-methoxy-2-oxoethylidene)azetidine-1-carboxylate

InChI Key

DHTIDVBYPXKXSK-UHFFFAOYSA-N

Boiling Point

303.271ºC at 760 mmHg

Flash Point

137.214ºC

Density

1.219 g/cm³

Exact Mass

227.11600

H-Bond Acceptor

H-Bond Donor

Upstream Synthesis Route 1

398489-26-4
21204-67-1

1105662-87-0

Reference: [1]Hamill, Rosalie; Jones, Benjamin; Pask, Christopher M.; Sridharan, Visuvanathar
[Tetrahedron Letters, 2019, vol. 60, # 16, p. 1126 - 1129]
[2]Current Patent Assignee: ABBVIE INC - US2015/210720, 2015, A1
Location in patent: Paragraph 0620
[3]Current Patent Assignee: ABBVIE INC - US9777020, 2017, B2
Location in patent: Page/Page column 101; 102
[4]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - WO2009/10488, 2009, A1
Location in patent: Page/Page column 47
[5]Le Manach, Claire; Dam, Jean; Woodland, John G.; Kaur, Gurminder; Khonde, Lutete P.; Brunschwig, Christel; Njoroge, Mathew; Wicht, Kathryn J.; Horatscheck, André; Paquet, Tanya; Boyle, Grant A.; Gibhard, Liezl; Taylor, Dale; Lawrence, Nina; Yeo, Tomas; Mok, Sachel; Eastman, Richard T.; Dorjsuren, Dorjbal; Talley, Daniel C.; Guo, Hui; Simeonov, Anton; Reader, Janette; Van Der Watt, Mariëtte; Erlank, Erica; Venter, Nelius; Zawada, Jacek W.; Aswat, Ayesha; Nardini, Luisa; Coetzer, Theresa L.; Lauterbach, Sonja B.; Bezuidenhout, Belinda C.; Theron, Anjo; Mancama, Dalu; Koekemoer, Lizette L.; Birkholtz, Lyn-Marie; Wittlin, Sergio; Delves, Michael; Ottilie, Sabine; Winzeler, Elizabeth A.; Smith, Dennis; Fidock, David A.; Street, Leslie J.; Basarab, Gregory S.; Duffy, James; Chibale, Kelly
[Journal of Medicinal Chemistry, 2021, vol. 64, # 4, p. 2291 - 2309]

Downstream Synthesis Route 1

1105662-87-0

1105662-89-2

Reference: [1]Current Patent Assignee: ABBVIE INC - US2015/210720, 2015, A1
Location in patent: Paragraph 0621
[2]Current Patent Assignee: ABBVIE INC - US9777020, 2017, B2
Location in patent: Page/Page column 102
[3]Current Patent Assignee: Novartis (w/o Sandoz); NOVARTIS AG - WO2009/10488, 2009, A1
Location in patent: Page/Page column 47
[4]Current Patent Assignee: TAISHO PHARMACEUTICAL HOLDINGS CO., LTD. - EP2881384, 2015, A1
Location in patent: Paragraph 0260

* For details of the synthesis route, please refer to the original source to ensure accuracy.