CAS
10343-58-5 Purity
40%
10343-58-5 Purity
40%
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2-Hydroxysebacic Acid
CAS
103963-71-9
Catalog Number
ACM103963719
Category
Main Products
Molecular Weight
218.25
Molecular Formula
C10H18O5
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Stereoselective Analysis of 2-Hydroxysebacic Acid
A. Muth, et al. Journal of inherited metabolic disease, 2003, 26, 583-592.
The metabolite 2-hydroxysebacic acid (2-HS) has been recognized as one of the most important biochemical markers of peroxisomal diseases. Stereic differences in 2-HS in urine from patients with Zellweger syndrome (ZS) were studied and compared with the enantiomeric distribution of 2-HS in urine samples from medium-chain triglyceride (MCT)-fed preterm infants.
Patients and methods
· Patients: Urine samples were obtained from 9 patients with ZS. Clinically, all had the classical features of ZS and all had elevated levels of VLCFA, abnormal plasma bile acids and decreased levels of plasmalogens in cultured skin ¢broblasts.
· Methods: (R), (S)-2-Hydroxysebacic acid dimethyl ester and (R)-3-hydroxysebacic acid dimethyl ester were synthesized in the laboratory. Hydroxydicarboxylic acids were converted to their respective methyl esters (acetyl chloridemethanol, 1:9 v/v, 10 min at 110°C) after lyophilization of the urine samples (1 ml). The methyl esters were then extracted with t-methylbutyl ether (1 ml) and concentrated to 50 ml prior to analysis.
July 19, 2024
Reliable Biomarker for Peroxisomal Disorders
I have found 2-Hydroxysebacic Acid from Alfa Chemistry to be a reliable biomarker for detecting peroxisomal disorders in children. This product has been essential in my research, specifically in identifying neonatal adrenoleukodystrophy and Zellweger syndrome through urine samples. Additionally, the ease of use and accuracy of the results have made this product invaluable in my scientific investigations. I highly recommend 2-Hydroxysebacic Acid for any researchers looking to study peroxisomal disorders.
What is the molecular formula of 2-Hydroxysebacic Acid?
The molecular formula is C10H18O5.
What are the synonyms for 2-Hydroxysebacic Acid?
The synonyms are 2-hydroxydecanedioic acid, 103963-71-9, and decanedioic acid, 2-hydroxy-.
What is the molecular weight of 2-Hydroxysebacic Acid?
The molecular weight is 218.25 g/mol.
When was 2-Hydroxysebacic Acid created?
It was created on August 8, 2005.
What is the IUPAC name of 2-Hydroxysebacic Acid?
The IUPAC name is 2-hydroxydecanedioic acid.
What is the InChI of 2-Hydroxysebacic Acid?
The InChI is "InChI=1S/C10H18O5/c11-8(10(14)15)6-4-2-1-3-5-7-9(12)13/h8,11H,1-7H2,(H,12,13)(H,14,15)".
What is the InChIKey of 2-Hydroxysebacic Acid?
The InChIKey is "LPIOYESQKJFWPQ-UHFFFAOYSA-N".
What is the canonical SMILES of 2-Hydroxysebacic Acid?
The canonical SMILES is "C(CCCC(C(=O)O)O)CCCC(=O)O".
What is the CAS number of 2-Hydroxysebacic Acid?
The CAS number is 103963-71-9.
What is the melting point of 2-Hydroxysebacic Acid?
The melting point is 118 - 121 °C.
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